1404580-20-6Relevant academic research and scientific papers
Indole functionalization via photoredox gold catalysis
Kaldas, Sherif J.,Cannillo, Alexandre,McCallum, Terry,Barriault, Louis
, p. 2864 - 2866 (2015)
The use of photoredox catalyst [Au2(dppm)2]Cl2 to initiate free-radical cyclizations onto indoles is reported. Excitation of the dimeric Au(I) photocatalyst for the reduction of unactivated bromoalkanes and bromoarenes is used for the generation of carbon-centered radicals. Previous to this work, reduction processes leading to indole functionalization utilizing photoredox catalysts were limited to activated benzylic or α-carbonyl-positioned bromoalkanes. This method offers a mild and safe alternative to organostannanes and pyrophoric initiators for access to high energy radicals that were previously inaccessible through catalytic or stoichiometric means.
Direct conversion of indoles to 3,3-difluoro-2-oxindoles via electrophilic fluorination
Lim, Yee Hwee,Ong, Qunxiang,Duong, Hung A.,Nguyen, Tuan Minh,Johannes, Charles W.
supporting information, p. 5676 - 5679 (2013/01/15)
3,3-Difluoro-2-oxindoles can be obtained directly from indoles in moderate yields via electrophilic fluorination using N-fluorobenzenesulfonimide as a mild fluorinating reagent. The presence of tert-butyl hydroperoxide during the reaction, together with additional heating after quenching the reaction with triethylamine, is beneficial to the formation of the desired product.
