1226219-73-3Relevant academic research and scientific papers
Synthesis of meta-(Indol-3-yl)phenols from Indoles and Cyclohexenone via Palladium(II)-Catalyzed Oxidative Heck Reaction and Dehydrogenative Aromatization in a One-Step Sequence
Son, Seung Hwan,Shin, Jeong-Won,Won, Hyuck-Jae,Yoo, Hyung-Seok,Cho, Yang Yil,Kim, Soo Lim,Jang, Yoon Hu,Park, Boyoung Y.,Kim, Nam-Jung
supporting information, p. 7467 - 7471 (2021/10/02)
Facile construction of a meta-(indol-3-yl)phenol framework with a wide substrate scope (a total of 25 compounds) via a palladium(II)-catalyzed oxidative Heck reaction and dehydrogenative aromatization in a one-step sequence is reported. This methodology affords a novel route for the privileged structures that are challenging to access via a direct link between indole and phenol, in a highly efficient and atom-economical manner.
Frustrated Lewis Pair Catalyzed Dehydrogenative Oxidation of Indolines and Other Heterocycles
Maier, Alexander F. G.,Tussing, Sebastian,Schneider, Tobias,Fl?rke, Ulrich,Qu, Zheng -Wang,Grimme, Stefan,Paradies, Jan
, p. 12219 - 12223 (2016/10/13)
An acceptorless dehydrogenation of heterocycles catalyzed by frustrated Lewis pairs (FLPs) was developed. Oxidation with concomitant liberation of molecular hydrogen proceeded in high to excellent yields for N-protected indolines as well as four other substrate classes. The mechanism of this unprecedented FLP-catalyzed reaction was investigated by mechanistic studies, characterization of reaction intermediates by NMR spectroscopy and X-ray crystal analysis, and by quantum-mechanical calculations. Hydrogen liberation from the ammonium hydridoborate intermediate is the rate-determining step of the oxidation. The addition of a weaker Lewis acid as a hydride shuttle increased the reaction rate by a factor of 2.28 through a second catalytic cycle.
Selective ruthenium-catalyzed N-alkylation of indoles by using alcohols
Baehn, Sebastian,Imm, Sebastian,Mevius, Kathleen,Neubert, Lorenz,Tillack, Annegret,Williams, Jonathan M. J.,Beller, Matthias
supporting information; experimental part, p. 3590 - 3593 (2010/07/05)
(Chemical Equation Presentation) Alcohols for alkylation! The first homogeneous-catalyzed N-alkylations of indoles with aliphatic alcohols proceed under transfer hydrogenation conditions. By the use of the Shvo catalyst and p-toluenesulfonic acid (PTSA) t
