122641-10-5

Basic information

• Product Name: 1-(2-MORPHOLINOETHYL)-2-THIOUREA
• Synonyms: 1-(2-MORPHOLINOETHYL)-2-THIOUREA
• CAS NO: 122641-10-5
• Molecular Formula: C₇H₁₅N₃OS
• Molecular Weight: 189.28
• Mol File: 122641-10-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 105-108°C
• Boiling Point: 321.9°C at 760 mmHg
• Flash Point: 148.5°C
• Appearance: /
• Density: 1.182g/cm³
• Vapor Pressure: 0.00029mmHg at 25°C
• Refractive Index: 1.562
• PKA: 14.62±0.70(Predicted)
• CAS DataBase Reference: 1-(2-MORPHOLINOETHYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-MORPHOLINOETHYL)-2-THIOUREA(122641-10-5)
• EPA Substance Registry System: 1-(2-MORPHOLINOETHYL)-2-THIOUREA(122641-10-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 122641-10-5(Hazardous Substances Data)

Usage

General Description

1-(2-Morpholinoethyl)-2-thiourea is a chemical compound commonly known for its role in biology as a potent inhibitor of the enzyme nitric oxide synthase, which catalyzes the production of nitric oxide. As a morpholino derivative, it is part of the family of synthetic molecules designed to selectively bind RNA. It is also used in the production of different pharmaceutical products, and in multiple scientific studies focused on cardiovascular, immunological, and neurological systems due to its effect on nitric oxide levels. 1-(2-MORPHOLINOETHYL)-2-THIOUREA exhibits a wide range of physiological effects, both beneficial and toxic, depending upon concentration, the specific biological system in question, and other factors.

InChI:InChI=1/C7H15N3OS/c8-7(12)9-1-2-10-3-5-11-6-4-10/h1-6H2,(H3,8,9,12)

Upstream product

• 63224-35-1 2-morpholinoethyl isothiocyanate 
• 90746-30-8 4-(2-aminoethyl)morpholine hydrochloride 

Downstream Products

• 1551600-87-3 C₂₈H₃₁N₃O₅S 
• 1160622-84-3 2,6-difluoro-N-(3-(2-((2-(4-morpholinyl)ethyl)amino)-5-(2-((2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinyl)amino)-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)benzamide 
• 1160623-91-5 2,5-difluoro-N-(3-(5-(2-((3-fluoro-4-(methyloxy)phenyl)amino)-4-pyrimidinyl)-2-((2-(4-morpholinyl)ethyl)amino)-1,3-thiazol-4-yl)phenyl)benzamide 

Relevant articles and documents

ANTIVIRAL COMPOUNDS AND USE THEREOF

The present invention relates to compounds of formula (I), their use as medicaments, in particular as broad spectrum antiviral agents, their combination with a further antiviral agent and relative pharmaceutical compositions. In particular, the compounds of the invention are useful in the treatment of a disease caused by an enveloped virus.

Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors

The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino-1,3-thiazolyl]-thiophene-2-carboxamidines is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities.