1551600-87-3Relevant academic research and scientific papers
Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers
Chen, Lin,Magesh, Sadagopan,Wang, Hong,Yang, Chung S.,Kong, Ah-Ng Tony,Hu, Longqin
, p. 940 - 943 (2014)
Novel iminothiazinylbutadienols and divinylpyrimidinethiones were designed and synthesized as analogues of curcumin with its diketone moiety masked as a heterocyclic adduct with thiourea. The chemical stability of these novel heterocyclic compounds was improved as compared to curcumin. They exhibit longer half-lives and do not react with nucleophilic thiols under physiological conditions. In an ARE-luciferase reporter assay, some of these new curcumin analogues are more effective ARE activators than curcumin and isothiocyanates.
