1226499-98-4 Usage
Uses
Used in Pharmaceutical Industry:
N2,N4-Bis(2,3-diMethyl-2H-indazol-6-yl)-2,4-pyriMidinediaMine is used as an impurity in the development and manufacturing of Pazopanib, an oral angiogenesis inhibitor. Its presence is crucial for the study and understanding of the drug's properties, efficacy, and potential side effects.
Used in Cancer Treatment Research:
As a Pazopanib dimer impurity, N2,N4-Bis(2,3-diMethyl-2H-indazol-6-yl)-2,4-pyriMidinediaMine may be used in research aimed at understanding the mechanisms of action and potential applications of Pazopanib in cancer treatment. This could involve studying its interactions with VEGFR and PDGFR, as well as its effects on angiogenesis and tumor growth.
Used in Drug Development and Quality Control:
N2,N4-Bis(2,3-diMethyl-2H-indazol-6-yl)-2,4-pyriMidinediaMine plays a role in the development and quality control of Pazopanib as a pharmaceutical product. Its presence in the drug may be monitored and controlled to ensure the safety, efficacy, and consistency of the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 1226499-98-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,6,4,9 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1226499-98:
(9*1)+(8*2)+(7*2)+(6*6)+(5*4)+(4*9)+(3*9)+(2*9)+(1*8)=184
184 % 10 = 4
So 1226499-98-4 is a valid CAS Registry Number.
1226499-98-4Relevant academic research and scientific papers
Process-Related Impurities of Pazopanib
Terentjeva, Svetlana,Muceniece, Dzintra,LūSis, Viesturs
, p. 2057 - 2068 (2019/08/20)
The main target of this study was to synthesize reference compounds for HPLC analysis of impurities, produced in Pazopanib synthesis. It is highly desirable that impurity standards are made available to help in developing an HPLC control method that could be suitable for use in the industrial process. To the best of our knowledge, most of these impurities are not commercially available and no synthetic methods have been reported. Potential impurities were synthesized, and their structures were established by various spectroscopy techniques.
