635702-60-2

Basic information

• Product Name: 2,3-dimethyl-2H-indazol-6-amine hydrochloride
• Synonyms: 2,3-dimethyl-2H-indazol-6-amine hydrochloride;2,3-Dimethyl-2H-indazol-6-amine monohydrochloride;2,3-Dimethyl-6-amino-2H-indazole hydrochloride;2H-Indazol-6-aMine,2,3-diMethyl-, hydrochloride (1:1);3-Methyl-6-nitro-1H-indazole hydrochloride;2H-Indazol-6-aMine,2,3-diMethyl-, hydrochloride;6-Amino-2,3-dimethyl-2H-indazole Hydrochloride;2,3-Dimethyl-2H-indazol-6-amine hydrochloride 2,3-Dimethyl-2H-indazol-6-amine monohydrochloride
• CAS NO: 635702-60-2
• Molecular Formula: C₉H₁₁N₃*ClH
• Molecular Weight: 197.66468
• EINECS: -0
• Mol File: 635702-60-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 2,3-dimethyl-2H-indazol-6-amine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dimethyl-2H-indazol-6-amine hydrochloride(635702-60-2)
• EPA Substance Registry System: 2,3-dimethyl-2H-indazol-6-amine hydrochloride(635702-60-2)

Safety Data

• Hazardous Substances Data: 635702-60-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11N3.ClH/c1-6-8-4-3-7(10)5-9(8)11-12(6)2;/h3-5H,10H2,1-2H3;1H

Upstream product

• 20191-74-6 2-ethyl-5-nitroaniline 
• 635702-59-9 3-methyl-6-nitro-1H-indazole sulfate 
• 6494-19-5 3-methyl-6-nitro-1H-indazole 
• 444731-73-1 2,3?dimethyl?6?nitro?2H?indazole 

Downstream Products

• 1226499-98-4 N2,N4-bis(2,3-dimethyl-2H-indazol-6-yl)-pyrimidine-2,4-diamine 
• 444731-74-2 N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine 

Relevant articles and documents

Method for preparing 2, 3-dimethyl-2H-indazole-6-benzylamine hydrochloride

The invention discloses a method for preparing 2, 3-dimethyl-2H-indazole-6-benzylamine hydrochloride. The method comprises the steps of reacting a glacial acetic acid solution of tert-butyl nitrite and a glacial acetic acid solution of 5-nitro-2-ethylaniline in a first microreactor to generate 3-methyl-6-nitro-1H-indazole; reacting a homogeneous solution formed by mixing the 3-methyl-6-nitro-1H-indazole and a dimethyl sulfoxide solution of methyl iodide and a dimethyl sulfoxide solution of sodium ethoxide in a second microreactor to generate 2,3-dimethyl-6-nitro-2H-indazole; then reacting withmixed liquor formed by stirring a concentrated hydrochloric acid solution of stannous chloride and ethyl alcohol in a third microreactor to generate the 2, 3-dimethyl-2H-indazole-6-benzylamine hydrochloride. The method provided by the invention has the advantages of less side reaction, high yield, simplification of a complicated multi-step synthesis process, low toxicity and pollution, low production cost, good product quality, environment friendliness, energy saving and high efficiency, and is suitable for industrialized application.

Treatment Method

The present invention is directed to methods of treating an ocular neovascular disorder in a mammal by administration of pyrimidine derivatives, benzodiazepinyl derivatives and pharmaceutical compositions containing the same. The invention encompasses methods of treating an ocular neovascular disorder by administration of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, (S)-3-oxo-8-[3-(pyridin-2-ylamino)-1-propyloxy]-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid or salts or solvates thereof. Combination therapies for the treatment of ocular neovascular disorders are also encompassed.

CANCER TREATMENT METHOD

The present invention relates to a method of treating cancer in a mammal by administration of pyrimidine derivatives and quinazoline derivatives. In particular, the method relates to a method of treating cancer by administration of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide or salts or solvates thereof, and N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methane sulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine, or salts or solvates thereof.