122663-21-2

Upstream product

• 100-39-0 benzyl bromide 
• 122663-19-8 (5S)-5-(hydroxymethyl)-1-methylpyrrolidin-2-one 
• 42435-88-1 (S)-methyl 1-methyl-5-oxopyrrolidine-2-carboxylate 
• 17342-08-4 (S)-Pyroglutaminol 
• 126407-79-2 (5S)-5-({[(tert-butyl)dimethylsilyl]oxy}methyl)-1-methylpyrrolidin-2-one 
• 106191-02-0 (S)-5-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-2-one 

Downstream Products

• 129896-90-8 2(S)-<(tert-butyloxycarbonyl)amino>-3-cyclohexyl-1(S)-hydroxy-1-(1-methyl-5(S)-<(benzyloxy)methyl>-2-oxopyrrolidin-3(S)-yl)propane 

Relevant academic research and scientific papers

Amidine pseudodisaccharides

The synthesis of several aminoglucopyranose-based amidine pseudodisaccharides is described. They may serve as glycosidase inhibitors by virtue of structural similarities to both the reducing and non-reducing pyranose units involved in glycolysis.

DI- OR TRIPEPTIDE RENIN INHIBITORS CONTAINING LACTAM CONFORMATIONAL RESTRICTION IN ACHPA

Enzyme di-or tripeptides of the formula: STR1 and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems which employ these novel peptides.

Renin Inhibitors Containing Conformationally Restricted P1-P1' Dipeptide Mimetics

A series of renin inhibitors containing lactam-bridged P1-P1' dipeptide mimetics based on the ACHPA (4(S)-amino-5-cyclohexyl-3(S)-hydroxypentanoic acid) design was studied.The inhibitors were obtained by aldol addition of various lac