122670-45-5Relevant academic research and scientific papers
ISOQUINOLINOL COMPOUNDS HAVING CARDIOTONIC AND PHOSPHODIESTERASE FRACTION III INHIBITING PROPERTIES AND/OR RENAL VASOLDILATING PROPERTIES
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, (2008/06/13)
Substituted 3-isoquinolinol compounds of the general formula that exhibit cardiotonic, renal vasodilating and phosphodiesterase fraction III properties are pharmacologically active in the treatment of cardiac conditions. Methods for synthesizing and using
Cardiotonic Agents. Synthesis and Inotropic Activity of a Series of Isoquinolin-3-ol Derivatives
Kanojia, Ramesh M.,Press, Jeffery B.,Lever, O. William,Williams, Louella,McNally, James J.,et al.
, p. 1363 - 1368 (2007/10/02)
A series of isoquinolin-3-ol derivatives (II) was prepared as analogues of the clinical cardiotonic agent bemarinone (ORF 16600,I).Although in many respects the structural requirements for the cardiotonic activity of II are similarto those of bemarinone, ceratin differences between the series were noted.Our structure-activity studies show that II is less sensitive to alkoxy-substitution effects than is I, and more significantly, 4-substitution of II by alkyl groups, halogen, or alkanecarboxylic acid derivatives enhances cardiotonic activity in II in contrast to I, wherein analogous substitution eliminated activity.A linear correlation between contractile force (CF) increase and cyclic nucleotide phosphodiesterase fraction III (PDE-III) inhibition by the title compounds was determined.The isoquinoline derivatives were characteristically short-acting cardiotonic agents with good potency and selectivity.
