1226710-91-3

Upstream product

• 879283-39-3 3-(2-aminophenyl)-4-methyl-1,3-thiazole-2(3H)-thione 
• 100-44-7 benzyl chloride 
• 55114-86-8 9-benzyl-3-methyl[1,3]thiazolo[3,2-a]benzimidazol-9-ium chloride 
• 20194-18-7 sodium phenyl-methanolate 
• 5268-73-5 3-methylthiazolo[3,2-a]benzoimidazole 

Relevant academic research and scientific papers

Access to N-thioalkenyl and N-(o-thio)aryl-benzimidazol-2-ones by ring opening of thiazolobenzimidazolium and benzimidazobenzothiazolium salts and C-O bond cleavage of an alkoxide

We report herein the synthesis of highly functionalized 1,3-dihydro-2H-benzimidazol-2-ones via a ring opening of thiazolo[3,2-a]benzimidazolium or benzimidazo[2,1-b][1,3]benzothiazol-6-ium salts and an unusual C-O bond cleavage of an alkoxide. A large variety of benzimidazolones bearing an original N-thioalkenyl or N-(o-thio)aryl group was obtained in high yields. The developed chemistry provides efficient and rapid access to the privileged benzimidazol-2-one scaffold.