122674-94-6

Basic information

• Product Name: Propanoic acid, 2-(3-chlorophenoxy)-, methyl ester, (S)-
• CAS NO: 122674-94-6
• Molecular Formula: C10H11ClO3
• Molecular Weight: 214.649
• Mol File: 122674-94-6.mol

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-(3-chlorophenoxy)-, methyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-(3-chlorophenoxy)-, methyl ester, (S)-(122674-94-6)
• EPA Substance Registry System: Propanoic acid, 2-(3-chlorophenoxy)-, methyl ester, (S)-(122674-94-6)

Safety Data

• Hazardous Substances Data: 122674-94-6(Hazardous Substances Data)

Upstream product

• 4878-14-2 2-(3-Chloro-phenoxy)-propionyl chloride 
• 101-10-0 2-(3-chlorophenoxy)propionic acid 
• 122623-81-8 methyl 2-(3-chlorophenoxy)propionate 

Relevant articles and documents

Enantioselective inhibition: a strategy for improving the enantioselectivity of biocatalytic systems

Dextromethorphan (DM) and levomethorphan (LM) were found to be effective enantioselective inhibitors of Candida cylindracea lipase-catalyzed hydrolysis of a variety of (±)-arlypropionic and (±)-(arloxy)propionic esters. The enantioselectivity of the biocatalytic resolution of (±)-methyl 2-(2,4-dichlorophenoxy)propionate (DCPP) was enhanced 20-fold in the presence of either DM or LM. A general model for enantioselective inhibition has been developed, and a quantitative expression has been derived to show the underlying parameters that govern enantioselective inhibition. To define the mechanism of action of DM, a series of kinetic inhibition experiments was conducted with enantiomerically pure (R)-(+)-DCPP and (S)-(-)-DCPP. The observed inhibition pattern was that of partial noncompetitive inhibition for (R)-(+)-DCPP and that of pure noncompetitive inhibition for (S)-(-)-DCPP.

Enzyme catalysed hydrolysis of chlorophenoxypropionates

We report on the enzymatic hydrolysis of methyl 2-phenoxypropionate and of the following chlorinated derivatives: methyl o-chloro-, m-chloro-, p-chloro-, and o,p-dichloro-2-phenoxypropionates. α-Chymotripsyn, lipase, and pig liver esterase have an R enantioselectivity whereas subtilisin has an S enantioselectivity.Enantiomeric excess (e.e.) cover a wide range (from 5 to 100percent).