1226783-62-5

Basic information

• Product Name: (2S)-2-(3-phenoxy-phenyl)-propan-1-ol
• Synonyms: (2S)-2-(3-phenoxy-phenyl)-propan-1-ol
• CAS NO: 1226783-62-5
• Molecular Weight: 228.291
• Mol File: 1226783-62-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2S)-2-(3-phenoxy-phenyl)-propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-(3-phenoxy-phenyl)-propan-1-ol(1226783-62-5)
• EPA Substance Registry System: (2S)-2-(3-phenoxy-phenyl)-propan-1-ol(1226783-62-5)

Safety Data

• Hazardous Substances Data: 1226783-62-5(Hazardous Substances Data)

Upstream product

• 59908-87-1 2-(3-phenoxy-phenyl)-propionaldehyde 
• 124-38-9 carbon dioxide 
• 63444-54-2 3-ethenylphenyl phenyl ether 

Downstream Products

• 33028-97-6 (S)-fenoprofen 
• 32852-92-9 3'-phenoxyacetophenone 

Relevant articles and documents

Highly Regio- and Enantioselective Copper-Catalyzed Reductive Hydroxymethylation of Styrenes and 1,3-Dienes with CO2

Herein, we report a highly regio- and enantioselective copper-catalyzed reductive hydroxymethylation of styrenes and 1,3-dienes with 1 atm of CO2. Diverse important chiral homobenzylic alcohols were readily prepared from styrenes. Moreover, a variety of 1,3-dienes also were converted to chiral homoallylic alcohols with high yields and excellent regio-, enantio-, and Z/E-selectivities. The utility of this transformation was demonstrated by a broad range of styrenes and 1,3-dienes, facile product modification, and synthesis of bioactive compounds (R)-(-)-curcumene and (S)-(+)-ibuprofen. Mechanistic studies demonstrated the carboxylation of phenylethylcopper complexes with CO2 as one key step.

Chemoenzymatic synthesis of (2S)-2-arylpropanols through a dynamic kinetic resolution of 2-arylpropanals with alcohol dehydrogenases

We applied Horse Liver Alcohol Dehydrogenase (HLADH) to the enantioselective synthesis of six (2S)-2-arylpropanols, useful intermediates in the synthesis of Profens. The influence of substrate structure and reaction conditions on yields and enantioselectivity were investigated. The high yields and high enantioselectivity towards the (S)-enantiomer obtained in the bioreduction of 2-arylpropionic aldehydes, clearly indicate the achievement of a DKR process through a combination of an enzyme-catalyzed kinetic reduction with a chemical base-catalyzed racemization of the unreacted aldehydes. The racemization step is represented by the keto-enol equilibrium of the aldehyde and can be controlled by modulating pH and reaction conditions.