122685-93-2

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 4703-19-9 N,N-diphenyl-p-toluenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 70-55-3 toluene-4-sulfonamide 

Relevant academic research and scientific papers

Palladium-Catalyzed ortho-Benzoylation of Sulfonamides through C?H Activation: Expedient Synthesis of Cyclic N-Sulfonyl Ketimines

The ortho-carbonylation of sulfonylarenes by non-hazardous aryl aldehydes as a carbonyl precursor was reported. In this method, the sulfonamide group serves as a directing group for C?H activation in the presence of a Pd catalyst under ligand-free conditions. The scope of this strategy has been extended to the one-pot two-step synthesis of cyclic N-sulfonyl ketimines under mild reaction conditions. Our approach could be considered as an alternative by circumventing the use of highly reactive organolithium or Grignard reagents to access a wide range of biologically potent cyclic N-sulfonyl ketimines. (Figure presented.).

A Facile One-Pot Procedure for the Synthesis of 1,2-Benzisothiazole 1,1-Dioxides

ortho-Lithiated N,N-diphenylbenzenesulfonamides 6 react with aromatic nitriles and N,N-dimethylcarbamonitrile, respectively, to give directly the corresponding 3-substituted 1,2-benzisothiazole-1,1-dioxides 8a-f.Other cyano compounds only transfer the cyano group or its ligands to generate the o-substituted benzenesulfonamides 9a-d.