122689-00-3

Upstream product

• 149049-60-5 isopropylidenediphenylsulfurane 
• 182505-58-4 toluene-4-sulfonic acid 5,5-dimethyl-4-oxocyclopent-2-enyl ester 
• 29787-20-0 3,3,6,6-tetramethylbicyclo[3.1.0]hexane-2,4-dione 
• 702-50-1 2,2,5,5-tetramethylcyclohexa-1,3-dione 
• 42050-54-4 4-exo-hydroxy-3,3,6,6-tetramethylbicyclo[3.1.0]hexan-2-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 42050-54-4 (1R,5S)-4-Hydroxy-3,3,6,6-tetramethyl-bicyclo[3.1.0]hexan-2-one 

Downstream Products

• 2935-23-1 cis-Chrysanthemic acid 

Relevant academic research and scientific papers

Novel synthesis of vinyl cyclopropane carboxylic acids: Application to the synthesis of (d,l)- and (d)-cis-chrysanthemic acid

Reaction of sulfur ylides with suitably 4-functionalized-5,5-dimethyl-2-cyclopentenones allows an efficient entry to the bicyclo[3.1.0]hexan-2-one skeleton which proved to be a valuable precursor of vinyl cyclopropane carboxylic acids. Application to the synthesis of (d,l)- and (d)-(cis)-chrysanthemic acid is described.

Comparison between 'IgY technology' from chickens and 'IgG technology' from mice for production of tailor-made antibodies

Antibodies collected from chickens immunized towards a β-ketoalcohol, key intermediate in the synthesis of chrysanthemic acid, which have been shown to possess similar behavior to those elaborated from mice, offer the enormous advantages of no bleeding and access to large quantities of antibodies by easy extraction of the yolk of the eggs.