1226910-75-3Relevant academic research and scientific papers
Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives
Kwak, Jae-Hwan,Kim, Yoseob,Park, Hyunjeong,Jang, Jae-Yong,Lee, Keun Kuk,Yi, Wonhui,Kwak, Jeong-Ah,Park, Song-Gyu,Kim, Hwanmook,Lee, Kiho,Kang, Jong Soon,Han, Sang-Bae,Hwang, Bang Yeon,Hong, Jin Tae,Jung, Jae-Kyung,Kim, Youngsoo,Cho, Jungsook,Lee, Heesoon
scheme or table, p. 4620 - 4623 (2010/10/02)
Chroman derivatives exhibited potent inhibitory activity of NF-κB. For SAR, the chroman scaffold was modified with an indoline moiety. A series of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives were synthesized to explore their inhibitory activities of NF-κB and they were also evaluated for cytotoxicity against various cancer cell lines. Since intermediates with Boc showed outstanding results, various substituents in place of the Boc group were introduced additionally and these compounds were also evaluated for SAR.
