137088-51-8

Basic information

• Product Name: 1-(TERT-BUTOXYCARBONYL)-2-INDOLINECARBOXYLIC ACID
• Synonyms: 1-BOC-INDOLINE-2-CARBOXYLIC ACID;2,3-DIHYDRO-INDOLE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;1-(TERT-BUTOXYCARBONYL)-2-INDOLINECARBOXYLIC ACID;1-(TERT-BUTYL) HYDROGEN INDOLINE-1,2-DICARBOXYLATE;INDOLINE-2-CARBOXYLIC ACID, N-BOC PROTECTED;BOC-INDOLINE-2-CARBOXYLIC ACID;1-t-butoxycarbonyl-2,3-dihydroindole-2-carboxylic acid;1-(tert-Butoxycarbonyl)-2,3-dihydro-1H-indole-2-carboxylic acid
• CAS NO: 137088-51-8
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.29
• Mol File: 137088-51-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 121-122
• Boiling Point: 411.6°Cat760mmHg
• Flash Point: 202.7°C
• Appearance: /
• Density: 1.259g/cm³
• Storage Temp.: 2-8°C
• PKA: 3.85±0.20(Predicted)
• CAS DataBase Reference: 1-(TERT-BUTOXYCARBONYL)-2-INDOLINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(TERT-BUTOXYCARBONYL)-2-INDOLINECARBOXYLIC ACID(137088-51-8)
• EPA Substance Registry System: 1-(TERT-BUTOXYCARBONYL)-2-INDOLINECARBOXYLIC ACID(137088-51-8)

Safety Data

• Hazardous Substances Data: 137088-51-8(Hazardous Substances Data)

Usage

General Description

1-(tert-Butoxycarbonyl)-2-indolinecarboxylic acid is a chemical compound that belongs to the family of indolinecarboxylic acids. It is commonly used as a key building block for the synthesis of various pharmaceutical compounds due to its versatile reactivity. 1-(TERT-BUTOXYCARBONYL)-2-INDOLINECARBOXYLIC ACID is known for its ability to undergo various functional group transformations, making it an important intermediate in the production of diverse drugs and biologically active molecules. Its tert-butoxycarbonyl group provides protection to the indolinecarboxylic acid functionality, allowing for selective modification and manipulation in organic synthesis. Additionally, its indoline ring structure also exhibits potential biological activity, making it a valuable target in medicinal chemistry research.

Upstream product

• 16851-56-2 indolin-2-yl carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 365250-59-5 2-(methoxymethyl)indoline 
• 656257-05-5 N-(t-butoxycarbonyl)-2-(methoxymethyl)indoline 
• 252357-58-7 2,3-dihydro-indole-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 
• 1400928-14-4 N,N-dimethylindoline-(2RS)-2-carboxamide 
• 1400928-23-5 C₂₄H₃₆N₄O₂ 
• 1400928-22-4 C₂₆H₃₄N₄O₂ 
• 1400928-20-2 C₂₄H₃₀N₄O₂ 
• 1400928-19-9 C₂₆H₃₄N₄O₃ 
• 1400928-17-7 C₂₆H₃₃N₃O₂ 
• 1400928-56-4 1-[3-(4-cyclohexylpiperazin-1-yl)propanoyl]-N,N-dimethylindoline-(2RS)-2-carboxamide monocitrate 
• 1400928-55-3 N,N-dimethyl-1-{3-[4-(1-phenylethyl)piperazin-1-yl]propanoyl}indoline-(2RS)-2-carboxamide monocitrate 
• 1400928-53-1 N,N-dimethyl-1-[3-(4-phenylpiperazin-1-yl)propanoyl]indoline-(2RS)-2-carboxamide monocitrate 
• 1400928-52-0 1-{3-[4-(2-ethoxyphenyl)piperazin-1-yl]propanoyl}-N,N-dimethylindoline-(2RS)-2-carboxamide monocitrate 
• 1400928-50-8 N,N-dimethyl-1-[3-(4-o-tolylpiperidin-1-yl)propanoyl]indoline-(2RS)-2-carboxamide monocitrate 

Relevant articles and documents

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives

Chroman derivatives exhibited potent inhibitory activity of NF-κB. For SAR, the chroman scaffold was modified with an indoline moiety. A series of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives were synthesized to explore their inhibitory activities of NF-κB and they were also evaluated for cytotoxicity against various cancer cell lines. Since intermediates with Boc showed outstanding results, various substituents in place of the Boc group were introduced additionally and these compounds were also evaluated for SAR.