122695-52-7

Upstream product

• 122695-55-0 Acetic acid 2-(2-hydroxy-5-oxo-pyrrolidin-1-yl)-ethyl ester 
• 103979-79-9 1-(3-ethoxycarbonyl-3-hydroxymethylenepropyl)-5-phenyl-thiopyrrolidin-2-one 
• 116071-86-4 5-ethoxy-1-(3-ethoxycarbonylpropyl)pyrrolidin-2-one 
• 103979-80-2 1-(3-diazo-3-ethoxycarbonylpropyl)-5-phenylthiopyrrolidin-2-one 
• 103979-78-8 4-(2-Oxo-5-phenylsulfanyl-pyrrolidin-1-yl)-butyric acid ethyl ester 
• 103979-77-7 1-(3-ethoxycarbonylpropyl)pyrrolidine-2,5-dione 
• 116071-98-8 1-(3-ethoxycarbonylpropyl)-5-hydroxypyrrolidin-2-one 
• 103979-81-3 6-ethoxycarbonyl-6-phenylthio-1-azabicyclo<3.3.0>octan-2-one 
• 122695-46-9 1-(2-acetoxyethyl)-5-acetoxy-2-pyrrolidinone 
• 28833-81-0 2-(2,5-dioxopyrrolidin-1-yl)ethyl acetate 
• 18190-44-8 1-(2-Hydroxy-ethyl)-pyrrolidine-2,5-dione 
• 122695-51-6 (S)-5-Oxo-1-phenylsulfanyl-hexahydro-pyrrolizine-1-carboxylic acid methyl ester 

Downstream Products

• 116071-96-6 6-hydroxymethyl-6-phenylsulphinyl-1-azabicyclo<3.3.0>octan-2-one 
• 92721-60-3 7-(hydroxymethyl)-1,2,5,7a-tetrahydro-3H-pyrrolizin-3-one 
• 17958-41-7 (+)-supinidine 
• 551-59-7 (-)-supinidine 

Relevant academic research and scientific papers

A Novel Synthesis of Pyrrolizidine Alkaloids by Means of an Intramolecular Carbenoid Displacement (ICD) Reaction

The pyrrolizidine alkaloids, (+/-)-trachelanthamidine, (+/-)-isoretronecanol, and (+/-)-supinidine were synthesized by using an intramolecular carbenoid displacement (ICD) reaction of the diazo-sulphide or the diazo-selenide derivatives as a key step.

NEW CHIRAL RECOGNITION OF CHIRAL TIN(II) ENOLATES TOWARD CYCLIC ACYL IMINIUM SPECIES. ASYMMETRIC TOTAL SYNTHESIS OF (-)-SUPINIDINE

Diastereoselective alkylation of chiral tin(II) enolates 1 onto cyclic acyl iminium ion 7 proceeded in a different chiral recognition mode from the case of 1 onto cyclic acyl imines 3.This new diastereoselective alkylation was efficiently utilized for an asymmetric total synthesis of (-)-supinidine (20).