1226950-76-0

Basic information

• Product Name: C₁₉H₂₅F₃N₄
• CAS NO: 1226950-76-0
• Molecular Weight: 366.43
• Mol File: 1226950-76-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₅F₃N₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₅F₃N₄(1226950-76-0)
• EPA Substance Registry System: C₁₉H₂₅F₃N₄(1226950-76-0)

Safety Data

• Hazardous Substances Data: 1226950-76-0(Hazardous Substances Data)

Upstream product

• 37832-54-5 4-piperidinecarboxylic acid hydrochloride 
• 1399035-84-7 2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine 
• 1399035-82-5 4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine acetic acid salt 
• 1399035-80-3 N-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}isonicotinamide hydrochloride 
• 1399383-53-9 N-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}isonicotinamide 
• 1082951-17-4 (2-amino-1-(4-fluoro, 3-trifluoromethyl-phenyl)-ethanone) p-toluenesulfonate 
• 55-22-1 pyridine-4-carboxylic acid 

Relevant articles and documents

A practical synthesis of 2-{4-[4-Fluoro-3-(trifluoromethyl)phenyl]-2- (piperidin-4-yl)-1H-imidazol-1-yl}- N, N -dimethylethanamine

A practical synthesis of the title compound was accomplished by hydrogenation of 2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H- imidazol-1-yl}-N,N-dimethylethanamine. The latter was obtained by N-alkylation of 4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine. Treatment of N-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl} isonicotinamide hydrochloride with ammonium acetate in acetic acid provided 4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine. Coupling of 2-amino-1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone 4-methylbenzene sulfonate with pyridine 4-carboxylic acid using either T3P or EDCI-HOBt provided N-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl} isonicotinamide hydrochloride. Georg Thieme Verlag Stuttgart New York.