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12-phenyl-4b,5-dihydro-6H-isoquinolino[2,1-a]quinazolin-6-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1226978-01-3

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1226978-01-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1226978-01-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,6,9,7 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1226978-01:
(9*1)+(8*2)+(7*2)+(6*6)+(5*9)+(4*7)+(3*8)+(2*0)+(1*1)=173
173 % 10 = 3
So 1226978-01-3 is a valid CAS Registry Number.

1226978-01-3Relevant articles and documents

Synthesis of Isoquinoline-Fused Quinazolinones through Ag(I)-Catalyzed Cascade Annulation of 2-Aminobenzamides and 2-Alkynylbenzaldehydes

Sonawane, Amol D.,Shaikh, Yunnus B.,Garud, Dinesh R.,Koketsu, Mamoru

, p. 500 - 507 (2019)

A new route for the expedient synthesis of a specific regioisomer of isoquinoline-fused quinazolinones is reported. Silver(I)-catalyzed cascade cyclization of 2-aminobenzamides and 2-alkynylbenzaldehydes followed by in situ oxidation gives 12-butyl-or 12-aryl-6 H-isoquinolino[2,1- A [quinazolin-6-ones in 69-91% yields. The structure of the isoquinoline-fused quinazolinone was confirmed by X-ray crystallography analysis.

Tuning the reactivity of Au-complexes in an Au(i)/chiral Bronsted acid cooperative catalytic system: An approach to optically active fused 1,2-dihydroisoquinolines

Patil, Nitin T.,Mutyala, Anil Kumar,Konala, Ashok,Tella, Ramesh Babu

, p. 3094 - 3096 (2012/04/17)

An enantioselective cooperative catalysis protocol, utilizing achiral Au(i) complexes and chiral Bronsted acids, has been developed for the synthesis of optically pure fused 1,2-dihydroisoquinolines starting from 2-alkynylbenzaldehydes and 2-aminobenzamides. The Royal Society of Chemistry 2012.

Yb(OTf)3 catalyzed new cascade reaction: A facile assembly of fused quinazolinones

Kumar, K. Siva,Kumar, P. Mahesh,Reddy, M. Appi,Ferozuddin, Md.,Sreenivasulu,Jafar, Ahamed A.,Krishna,Reddy, C. Malla,Rambabu,Shiva Kumar,Pal, Sarbani,Pal, Manojit

supporting information; experimental part, p. 10263 - 10265 (2011/10/31)

A one-pot Yb(iii)-mediated cascade reaction has been developed leading to small molecules based on a novel structural motif, i.e. quinazolin-4-one moiety fused with an isoquinoline ring, for potential inhibition of TNF-α.

Facile assembly of fused isoquinolines by gold(i)-catalyzed coupling-cyclization reactions between o-alkynylbenzaldehydes and aromatic amines containing tethered nucleophiles

Patil, Nitin T.,Mutyala, Anil Kumar,Pediredla, G. V. V. Lakshmi,Penmatcha, V. K. Raju,Balasubramanian, Sridhar

supporting information; experimental part, p. 1999 - 2007 (2010/06/15)

A gold(I)-catalyzed, operationally simple coupling-cyclization technique was developed for the synthesis of isoquinoline-fused polycyclic compounds. The reaction makes use of two coupling partners such as o-alkynylbenzaldehydes and aromatic amines having tethered nucleophiles. The reaction is easy to perform, broad in scope, and allows the generation of a number of biologically important heterocyclic motifs from readily accessible starting materials. A mechanism for the reaction is discussed.

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