1226978-01-3

Basic information

• Product Name: 12-phenyl-4b,5-dihydro-6H-isoquinolino[2,1-a]quinazolin-6-one
• Synonyms: 12-phenyl-4b,5-dihydro-6H-isoquinolino[2,1-a]quinazolin-6-one
• CAS NO: 1226978-01-3
• Molecular Weight: 324.382
• Mol File: 1226978-01-3.mol

Chemical Properties

• CAS DataBase Reference: 12-phenyl-4b,5-dihydro-6H-isoquinolino[2,1-a]quinazolin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 12-phenyl-4b,5-dihydro-6H-isoquinolino[2,1-a]quinazolin-6-one(1226978-01-3)
• EPA Substance Registry System: 12-phenyl-4b,5-dihydro-6H-isoquinolino[2,1-a]quinazolin-6-one(1226978-01-3)

Safety Data

• Hazardous Substances Data: 1226978-01-3(Hazardous Substances Data)

Upstream product

• 59046-72-9 o-(phenylethynyl)benzaldehyde 
• 28144-70-9 anthranilic acid amide 
• 118-48-9 isatoic anhydride 
• 506-87-6 ammonium carbonate 

Downstream Products

• 1364406-59-6 12-phenyl-6H-isoquinolino[2,1-a]quinazolin-6-one 

Relevant articles and documents

Synthesis of Isoquinoline-Fused Quinazolinones through Ag(I)-Catalyzed Cascade Annulation of 2-Aminobenzamides and 2-Alkynylbenzaldehydes

A new route for the expedient synthesis of a specific regioisomer of isoquinoline-fused quinazolinones is reported. Silver(I)-catalyzed cascade cyclization of 2-aminobenzamides and 2-alkynylbenzaldehydes followed by in situ oxidation gives 12-butyl-or 12-aryl-6 H-isoquinolino[2,1- A [quinazolin-6-ones in 69-91% yields. The structure of the isoquinoline-fused quinazolinone was confirmed by X-ray crystallography analysis.

Tuning the reactivity of Au-complexes in an Au(i)/chiral Bronsted acid cooperative catalytic system: An approach to optically active fused 1,2-dihydroisoquinolines

An enantioselective cooperative catalysis protocol, utilizing achiral Au(i) complexes and chiral Bronsted acids, has been developed for the synthesis of optically pure fused 1,2-dihydroisoquinolines starting from 2-alkynylbenzaldehydes and 2-aminobenzamides. The Royal Society of Chemistry 2012.

Yb(OTf)3 catalyzed new cascade reaction: A facile assembly of fused quinazolinones

A one-pot Yb(iii)-mediated cascade reaction has been developed leading to small molecules based on a novel structural motif, i.e. quinazolin-4-one moiety fused with an isoquinoline ring, for potential inhibition of TNF-α.

Facile assembly of fused isoquinolines by gold(i)-catalyzed coupling-cyclization reactions between o-alkynylbenzaldehydes and aromatic amines containing tethered nucleophiles

A gold(I)-catalyzed, operationally simple coupling-cyclization technique was developed for the synthesis of isoquinoline-fused polycyclic compounds. The reaction makes use of two coupling partners such as o-alkynylbenzaldehydes and aromatic amines having tethered nucleophiles. The reaction is easy to perform, broad in scope, and allows the generation of a number of biologically important heterocyclic motifs from readily accessible starting materials. A mechanism for the reaction is discussed.