1226978-01-3Relevant articles and documents
Synthesis of Isoquinoline-Fused Quinazolinones through Ag(I)-Catalyzed Cascade Annulation of 2-Aminobenzamides and 2-Alkynylbenzaldehydes
Sonawane, Amol D.,Shaikh, Yunnus B.,Garud, Dinesh R.,Koketsu, Mamoru
, p. 500 - 507 (2019)
A new route for the expedient synthesis of a specific regioisomer of isoquinoline-fused quinazolinones is reported. Silver(I)-catalyzed cascade cyclization of 2-aminobenzamides and 2-alkynylbenzaldehydes followed by in situ oxidation gives 12-butyl-or 12-aryl-6 H-isoquinolino[2,1- A [quinazolin-6-ones in 69-91% yields. The structure of the isoquinoline-fused quinazolinone was confirmed by X-ray crystallography analysis.
Tuning the reactivity of Au-complexes in an Au(i)/chiral Bronsted acid cooperative catalytic system: An approach to optically active fused 1,2-dihydroisoquinolines
Patil, Nitin T.,Mutyala, Anil Kumar,Konala, Ashok,Tella, Ramesh Babu
, p. 3094 - 3096 (2012/04/17)
An enantioselective cooperative catalysis protocol, utilizing achiral Au(i) complexes and chiral Bronsted acids, has been developed for the synthesis of optically pure fused 1,2-dihydroisoquinolines starting from 2-alkynylbenzaldehydes and 2-aminobenzamides. The Royal Society of Chemistry 2012.
Yb(OTf)3 catalyzed new cascade reaction: A facile assembly of fused quinazolinones
Kumar, K. Siva,Kumar, P. Mahesh,Reddy, M. Appi,Ferozuddin, Md.,Sreenivasulu,Jafar, Ahamed A.,Krishna,Reddy, C. Malla,Rambabu,Shiva Kumar,Pal, Sarbani,Pal, Manojit
supporting information; experimental part, p. 10263 - 10265 (2011/10/31)
A one-pot Yb(iii)-mediated cascade reaction has been developed leading to small molecules based on a novel structural motif, i.e. quinazolin-4-one moiety fused with an isoquinoline ring, for potential inhibition of TNF-α.
Facile assembly of fused isoquinolines by gold(i)-catalyzed coupling-cyclization reactions between o-alkynylbenzaldehydes and aromatic amines containing tethered nucleophiles
Patil, Nitin T.,Mutyala, Anil Kumar,Pediredla, G. V. V. Lakshmi,Penmatcha, V. K. Raju,Balasubramanian, Sridhar
supporting information; experimental part, p. 1999 - 2007 (2010/06/15)
A gold(I)-catalyzed, operationally simple coupling-cyclization technique was developed for the synthesis of isoquinoline-fused polycyclic compounds. The reaction makes use of two coupling partners such as o-alkynylbenzaldehydes and aromatic amines having tethered nucleophiles. The reaction is easy to perform, broad in scope, and allows the generation of a number of biologically important heterocyclic motifs from readily accessible starting materials. A mechanism for the reaction is discussed.