1227005-52-8Relevant academic research and scientific papers
Synthesis and evaluation of novel 3,4-epoxypiperidines as efficient DNA alkylating agents
Kawada, Yuji,Kodama, Tetsuya,Miyashita, Kazuyuki,Imanishi, Takeshi,Obika, Satoshi
, p. 1249 - 1265 (2010)
3,4-Epoxypiperidine derivatives are novel DNA alkylating agents based on an active site of the antitumor antibiotics azinomycins A and B. A 3,4-epoxypiperidine library was constructed containing derivatives with a variety of functional groups at C5 via Huisgen reaction, and DNA cleavage activity was examined. Results revealed a more active derivative than any 3,4-epoxypiperidines previously reported.
