74489-49-9Relevant articles and documents
SELECTIVE DRUG RELEASE FROM INTERNALIZED CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS
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, (2021/04/01)
The invention relates to conjugates of biologically active compounds, wherein such a conjugate is comprised of a sequence of amino acids containing a tripeptide that confers selective cleavage by tumor tissue homogenate for release of free drug and/or imp
BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF
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Paragraph 00269; 00272, (2021/08/14)
The present invention relates to novel bioprobes which are capable of binding to certain amine oxidase enzymes. These bioprobes are useful in methods of detecting and determining the concentration of certain amine oxidase enzymes in a sample as well as in methods for the quantitative assessment of inhibition of certain amine oxidases.
Phthalimide selective androgen receptor degradation agent as well as preparation method and application thereof
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Paragraph 0019, (2020/03/06)
The invention discloses phthalimide chimeric molecules containing 1, 2, 3-triazolyl, a preparation method of the phthalimide chimeric molecules and application of the phthalimide chimeric molecules serving as selective androgen receptor (AR) inhibitors in the field of AR high-expression cancer resistance, and belongs to the field of medicinal chemistry. The compounds have a structural general formula disclosed in the invention; the compounds have a good binding effect on AR, have AR degradation activity, and can be used as candidates for further development or lead compounds for preparing anti-AR-high-expression cancer drugs.