1227009-01-9Relevant academic research and scientific papers
2190-2192 Cooperative catalysis in multicomponent reactions: Highly enantioselective synthesis of γ-hydroxyketones with a quaternary carbon stereocenter
Guan, Xiao-Yu,Yang, Li-Ping,Hu, Wenhao
, p. 2190 - 2192 (2010)
Chemical Equation Presented Together they make a difference: An aryl diazoacetate, H2O, and an α, β-unsaturated 2-acyl imidazole give γ-hydroxyketones with a quaternary carbon stereocenter with excellent selectivity only if all three catalyst components shown in the scheme are present. The Michael addition step did not occur when a similar reagent mixture was treated with the [Rh2(OAc)4] catalyst alone. OTf=triflate, Ts = p-tosyl.
