1227158-52-2

Basic information

• Product Name: 4-(6-(PhenylaMino)pyridin-3-yl)pyriMidin-2-aMine
• Synonyms: 4-(6-(PhenylaMino)pyridin-3-yl)pyriMidin-2-aMine
• CAS NO: 1227158-52-2
• Molecular Formula: C₁₅H₁₃N₅
• Molecular Weight: 263.3
• Mol File: 1227158-52-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(6-(PhenylaMino)pyridin-3-yl)pyriMidin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(6-(PhenylaMino)pyridin-3-yl)pyriMidin-2-aMine(1227158-52-2)
• EPA Substance Registry System: 4-(6-(PhenylaMino)pyridin-3-yl)pyriMidin-2-aMine(1227158-52-2)

Safety Data

• Hazardous Substances Data: 1227158-52-2(Hazardous Substances Data)

Upstream product

• 1234327-10-6 (E)-3-(dimethylamino)-1-(6-(phenylamino)pyridin-3-yl)prop-2-en-1-one 
• 50-01-1 guanidine hydrochloride 

Downstream Products

• 1234327-15-1 N-(3,5-bis(trifluoromethyl)phenyl)-4-(6-(phenylamino)-pyridin-3-yl)pyrimidin-2-amine 

Relevant articles and documents

Design and synthesis of new anticancer pyrimidines with multiple-kinase inhibitory effect

A new series of N-substituted-2-aminopyrimidines based on the '4-(pyridin-3-yl)pyrimidin-2-amine' scaffold of Imatinib has been designed and synthesized. A selected group from the target compounds was tested over a panel of 60 cancer cell lines at a single dose concentration of 10 μM, and the two most active compounds, 25b and 30, were further tested in a five-dose testing mode to determine their IC50 values over the 60 cell lines. Compound 30 has showed good potencies and high efficacies, and was accordingly tested at a single dose concentration of 10 μM over a panel of 54 kinases. At this concentration, the compound has showed multiple inhibitions over a number of oncogenic kinases, including ABL1, AKT1, LCK, C-SRC, PIM1, FLT3, FYN, and KDR. A molecular modeling study was made by docking of the most active compound 30 and its inactive analog 29 into the kinase domain of ABL1 to investigate their possible binding interactions.