122733-39-5

Basic information

• Product Name: 2-methyl-5-(3-nitrophenyl)-1,3,4-oxadiazole
• Synonyms: 2-methyl-5-(3-nitrophenyl)-1,3,4-oxadiazole
• CAS NO: 122733-39-5
• Molecular Formula: C₉H₇N₃O₃
• Molecular Weight: 205.17018
• Mol File: 122733-39-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 156-158 °C(Solv: ethanol (64-17-5))
• Boiling Point: 367.9±44.0 °C(Predicted)
• Appearance: /
• Density: 1.349±0.06 g/cm3(Predicted)
• PKA: -4.30±0.32(Predicted)
• CAS DataBase Reference: 2-methyl-5-(3-nitrophenyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-5-(3-nitrophenyl)-1,3,4-oxadiazole(122733-39-5)
• EPA Substance Registry System: 2-methyl-5-(3-nitrophenyl)-1,3,4-oxadiazole(122733-39-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 122733-39-5(Hazardous Substances Data)

Usage

Uses

2-Methyl-5-(3-nitro-phenyl)-[1,3,4]oxadiazole (cas# 122733-39-5) is used in the synthetic preparation of acyl-?coenzyme A acting as cholesterol acyltransferase inhibitor for inhibiting cholesterol absorption.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 28, p. 1229, 1991 DOI: 10.1002/jhet.5570280513

Upstream product

• 78-39-7 Triethyl orthoacetate 
• 127-19-5 N,N-dimethyl acetamide 
• 618-94-0 3-nitrobenzoic acid hydrazide 
• 1445-45-0 Trimethyl orthoacetate 
• 21871-44-3 5-(3-nitrophenyl)-1H-tetrazole 
• 108-24-7 acetic anhydride 
• 54571-03-8 3-nitrobenzoic acid N'-acetylhydrazide 
• 126175-90-4 3-(3-Nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.4]non-2-en-4-ylamine 
• 137557-43-8 N-[3-(3-Nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.4]non-2-en-4-yl]-acetamide 
• 21871-44-3 5-(3-nitrophenyl)-2H-tetrazole 

Downstream Products

• 122733-40-8 3-(5-methyl-[1,3,4]oxadiazol-2-yl)-phenylamine 

Relevant articles and documents

TiCl4 mediated facile synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles

An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles has been developed. Various hydrazides or thionyl hydrazides readily react with DMA derivatives in the presence of TiCl4 as a catalyst to afford the desired products. This protocol provides a simple and economical procedure that affords the target products with good yields and wide substrate scope.

Microwave promoted one-pot synthesis of 2-aryl substituted 1,3,4-oxadiazoles and 1,2,4-oxadiazole derivatives using Al3+-K10 clay as a heterogeneous catalyst

An efficient, inexpensive method is developed for the one-pot synthesis of 2-aryl substituted 1,3,4-oxadiazoles and 1,2,4-oxadiazoles starting from acid hydrazides and trimethyl orthoformate under solvent-free, microwave conditions using a reusable Alsup

ARYLUREA DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

A compound of formula (I), wherein substituents are as given above, useful in the treatment of a disease mediated by the action of CCR3, in particular inflammatory or obstructive airway diseases.