1227459-41-7

Upstream product

• 882-26-8 (E)-1-nitro-3-(2-nitrovinyl)benzene 
• 78-84-2 isobutyraldehyde 
• 882-26-8 3-nitro-β-nitrostyrene 

Relevant academic research and scientific papers

Highly enantioselective Michael addition of α,α-disubstituted aldehydes to nitroolefins

A highly enantioselective Michael addition reaction of α,α-disubstituted aldehydes to β-nitrostyrenes has been developed. In the presence of rosin-based chiral primary amine-thiourea, γ-nitroaldehydes were afforded in excellent enantioselectivities (up to

Chiral Primary Amine-Squaramide Catalyzed Highly Enantioselective Michael Addition of Isobutyraldehyde to Nitroolefins

Chiral primary amine-squaramides have not been extensively studied to date in the field of organocatalysis. In this paper, novel chiral squaramides derived from natural product stevioside were developed. Both enantiomers of a series of γ-nitroaldehydes we

Magnetic Nanoparticles-Supported Chiral Catalyst with an Imidazolium Ionic Moiety: An Efficient and Recyclable Catalyst for Asymmetric Michael and Aldol Reactions

A magnetic nanoparticles-supported chiral aminocyclohexane in combination with sulfamide, which was modified by an imidazolium ionic moiety, was prepared and characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), transm

A kind of high-efficient load catalyst catalytic asymmetric Michael addition reaction method

The invention relates to a method for asymmetric Michael addition of isobutyraldehyde and nitroolefin under the indoor temperature reaction conditions by adopting an efficient and environment-friendly chiral supported catalyst and a water solvent. The method comprises steps as follows: superparamagnetic nanoparticle supported and ionic atmosphere modified chiral micromolecules are taken as a catalyst, N, N-DMAP (dimethylaminopyridine) is taken as an accelerant, isobutyraldehyde and nitroolefin have a stereoselective Michael addition reaction under the normal pressure at the temperature of 25 DEG C, and the reaction yield and the ee value are not remarkably reduced after the supported catalyst is repeatedly used for five times. The method is simple to operate, the stereoselectivity of the catalyst is good, the recycling is simple, a catalytic reaction system has good reusability, the reaction condition is mild, and large-scale production is easy to realize.

Highly enantioselective Michael additions of isobutyraldehyde to nitroalkenes promoted by amphiphilic bifunctional primary amine-thioureas in organic or aqueous medium

A novel class of chiral amphiphilic bifunctional thioureas based on a beyerane scaffold and each containing a primary amino group were designed and synthesized from the readily available natural product isosteviol. The thioureas were shown to be effective

Highly enantioselective michael addition of ketones and an aldehyde to nitroalkenes catalyzed by a binaphthyl sulfonimide in water

A binaphthyl sulfonimide organocatalyst was used to promote highly enantioselective and diastereoselective Michael addition reactions of ketones to nitroalkenes in water. In most cases, the products were obtained in good yields with excellent enantioselec

Highly asymmetric Michael additions of α,α-disubstituted aldehydes to β-nitroalkenes promoted by chiral pyrrolidine-thiourea bifunctional catalysts

A series of secondary amine-thiourea catalysts derived from l-proline and chiral diamine were prepared and first applied to the Michael addition of α,α-disubstituted aldehydes to trans-β-nitroalkenes. Moderate yields (47-75%) and excellent enantioselectiv

Highly enantioselective Michael addition of isobutyraldehyde to nitroalkenes

The asymmetric catalytic Michael reaction between isobutyraldehyde and nitroalkanes with chiral primary amine thiourea organocatalysts was described. In the presence of 10 mol % of 1-((1R,2R)-2-amino-1,2-diphenylethyl)-3-benzylthiourea, the desired produc