1227477-19-1

Basic information

• Product Name: C₂₀H₂₀ClF₃N₂O₃
• Synonyms: C₂₀H₂₀ClF₃N₂O₃
• CAS NO: 1227477-19-1
• Molecular Weight: 428.839
• Mol File: 1227477-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₀ClF₃N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₀ClF₃N₂O₃(1227477-19-1)
• EPA Substance Registry System: C₂₀H₂₀ClF₃N₂O₃(1227477-19-1)

Safety Data

• Hazardous Substances Data: 1227477-19-1(Hazardous Substances Data)

Upstream product

• 139163-43-2 (S)-2-amino-3,3-dimethylbutanoic acid hydrochloride 
• 1469996-69-7 2-(benzyloxy)-5-chloro-N-[(2S)-3,3-dimethyl-1-oxo-1-[[3-(trifluoromethyl)phenyl]amino]butan-2-yl]benzamide 
• 1469996-57-3 methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3,3-dimethyl]butanoate 
• 63038-27-7 L-tert-leucine methyl ester hydrochloride 

Relevant articles and documents

Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines

Variously substituted 2-hydroxy-N-(arylalkyl)benzamides were prepared and screened for antiproliferative and cytotoxic activity in cancer cell lines in vitro. Five compounds, out of 33 showed single-digit micromolar IC50 values against several human cancer cell lines. One of the most potent compounds N-((R)-1-(4-chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (6k) reduced proliferation and induced apoptosis in the melanoma cell line G361 in a dose-dependent manner, as shown by decrease in 5-bromo-2′- deoxyuridine incorporation and increase in several apoptotic markers, including subdiploid population increase, activation of caspases and site-specific poly-(ADP-ribose)polymerase (PARP) cleavage.