139163-43-2

Basic information

• Product Name: L-tert-Leucine hydrochloride
• Synonyms: L-TERT-LEUCINE HYDROCHLORIDE;(S)-2-amino-3,3-dimethylbutanoic acid hydrochlorid;(S)-2-Amino-3,3-dimethylbutanoic acid hydrochloride
• CAS NO: 139163-43-2
• Molecular Formula: C₆H₁₃NO₂*ClH
• Molecular Weight: 167.63
• Product Categories: Amino Acids & Deriv.;CHIRAL CHEMICALS
• Mol File: 139163-43-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: >300°C
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: L-tert-Leucine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-tert-Leucine hydrochloride(139163-43-2)
• EPA Substance Registry System: L-tert-Leucine hydrochloride(139163-43-2)

Safety Data

• Hazardous Substances Data: 139163-43-2(Hazardous Substances Data)

Usage

General Description

L-tert-Leucine hydrochloride is a chemical compound that is a derivative of the amino acid leucine. It is a white crystalline powder that is soluble in water. L-tert-Leucine hydrochloride is commonly used as a chiral auxiliary in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also used as a building block in the preparation of other chemical compounds and in the preparation of peptides and peptidomimetics. Additionally, it has been studied for its potential anti-cancer and neuroprotective properties, making it a compound of interest for scientific research.

Upstream product

• 33105-81-6 2-amino-3,3-dimethylbutanoic acid 
• 62965-57-5 (S)-(+)-2-amino-3,3-dimethylbutanamide 
• 175226-69-4 (5R)-3-tert-butyl-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one 
• 929220-40-6 N-benzyl-N-(1-cyano-2,2-dimethyl-propyl)-acetamide 
• 175416-53-2 (5R)-3-tert-butyl-5-phenyl-3,4,5,6-tetrahydro-1,4-oxazin-2-one 
• 1775-74-2 N-(2,2-dimethylpropylidene)benzylamine 
• 929220-45-1 C₁₅H₂₁NO₃ 

Downstream Products

• 132684-60-7 (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylbutanoic acid 
• 1092539-96-2 (S)-2-(d3-methoxy-carbonylamino)-3,3-d9-dimethylbutanoic acid 
• 20859-02-3 L-tert-Leucine 
• 63038-27-7 L-tert-leucine methyl ester hydrochloride 
• 1469996-69-7 2-(benzyloxy)-5-chloro-N-[(2S)-3,3-dimethyl-1-oxo-1-[[3-(trifluoromethyl)phenyl]amino]butan-2-yl]benzamide 
• 1469996-64-2 (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3,3-dimethylbutanoic acid 
• 1469996-57-3 methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3,3-dimethyl]butanoate 
• 1227477-19-1 C₂₀H₂₀ClF₃N₂O₃ 

Relevant articles and documents

Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging α-Amino Acids

Structurally simple and inexpensive chiral tridentate ligands were employed for substantially advancing the purely chemical dynamic kinetic resolution (DKR) of unprotected racemic tailor-made α-amino acids (TM-α-AAs), enabling the first DKR of TM-α-AAs bearing tertiary alkyl chains as well as multiple unprotected functional groups. Owing to the operationally convenient conditions, virtually complete stereoselectivity, and full recyclability of the source of chirality, this method should find wide applications for the preparation of TM-α-AAs, especially on large scale. The non-enzymatic dynamic kinetic resolution of racemic α-amino acids bearing tertiary alkyl chains and multiple unprotected functional groups is based on the enantioselective formation of nickel(II) complexes and their hydrolysis under convenient conditions. The specially designed chiral ligands are inexpensive and can be quantitatively recycled.

PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE tert-LEUCINE

Enantiomerically pure L-tert-leucine and D-tert-leucine were prepared from (DL)-tert-leucine by diastereomeric salt formation using dibenzoyl-d-tartaric acid as the resolving agent.

Catalytic asymmetric acylcyanation of imines

(Chemical Equation Presented) The less problematic acetyl cyanide can be used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of Jacobsen's catalyst 1, the desire