122751-41-1

Basic information

• Product Name: Z-Asp(OBzl)-OPyCl
• Synonyms: Z-Asp(OBzl)-OPyCl
• CAS NO: 122751-41-1
• Molecular Weight: 468.894
• Mol File: 122751-41-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Z-Asp(OBzl)-OPyCl(CAS DataBase Reference)
• NIST Chemistry Reference: Z-Asp(OBzl)-OPyCl(122751-41-1)
• EPA Substance Registry System: Z-Asp(OBzl)-OPyCl(122751-41-1)

Safety Data

• Hazardous Substances Data: 122751-41-1(Hazardous Substances Data)

Upstream product

• 16879-02-0 6-chloro-2-hydroxypyridine 
• 3479-47-8 Z-Asp(OBzl)-OH 

Downstream Products

• 5262-07-7 Z-Asp(OBzl)-Phe-OMe 
• 51871-02-4 Z-Asp(OBzl)-Ser-OMe 

Relevant articles and documents

Amino acids and peptides. XXIII. Synthesis of N alpha-protected amino acid 6-chloro-2-pyridyl esters and their evaluation for peptide synthesis.

6-Chloro-2-pyridyl esters (OPyCl) of N alpha-benzyloxycarbonyl and tert-butyloxycarbonylamino acids were synthesized by the N,N'-dicyclohexylcarbodiimide (DCC) method from the acids and 6-chloro-2-hydroxypyridine in dimethylformamide (DMF). The reactivity of the 6-chloro-2-pyridylester with amino group is much higher than that of the corresponding 2-pyridyl ester (OPy) and p-nitrophenyl esters (ONp) in dioxane and DMF, and a peptide bond is formed without acylation at the side chain hydroxyl group of amino acids. Z-Asp(OBzl)-OPyCl reacted with amino acid methyl esters in dioxane to give the corresponding dipeptide without any detectable aspartimide formation.