1227635-48-4

Basic information

• Product Name: α-benzyl-N-benzyloxycarbonylpyrrolidine
• Synonyms: α-benzyl-N-benzyloxycarbonylpyrrolidine
• CAS NO: 1227635-48-4
• Molecular Weight: 295.381
• Mol File: 1227635-48-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: α-benzyl-N-benzyloxycarbonylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: α-benzyl-N-benzyloxycarbonylpyrrolidine(1227635-48-4)
• EPA Substance Registry System: α-benzyl-N-benzyloxycarbonylpyrrolidine(1227635-48-4)

Safety Data

• Hazardous Substances Data: 1227635-48-4(Hazardous Substances Data)

Upstream product

• 31970-04-4 1-carboxybenzyl-3-pyrrolidine 
• 100-39-0 benzyl bromide 
• 88001-42-7 benzyl 2-methoxypyrrolidine-1-carboxylate 
• 6921-34-2 benzylmagnesium chloride 

Downstream Products

• 88001-42-7 benzyl 2-methoxypyrrolidine-1-carboxylate 

Relevant articles and documents

Ligand-Controlled Regiodivergent Hydroalkylation of Pyrrolines

Nickel hydride (NiH) catalyzed hydrocarbonation has emerged as an efficient approach to construct new C?C bonds containing at least one C(sp3) center. However, the regioselectivity of this reaction is by far dictated by substrates. Described here is a strategy to achieve two different regioselectivites of hydroalkylation of the same substrates by using ligand control. This strategy enables the first regiodivergent hydroalkylation of 3-pyrrolines, yielding both 2- and 3-alkylated pyrrolidines, valuable synthetic intermediates and common motifs in many bioactive molecules. This method demonstrates broad scope and high functional-group tolerance, and can be applied in late-stage functionalizations.