122772-21-8

Basic information

• Product Name: AKOS BBS-00003377
• Synonyms: AKOS BBS-00003377;TIMTEC-BB SBB009834;4-Allyl-5-(3,4-dimethoxyphenyl)-4H-1,2,4-triazole-3-thiol;4-allyl-5-(3,4-dimethoxyphenyl)-2H-1,2,4-triazole-3-thione;5-(3,4-dimethoxyphenyl)-4-prop-2-enyl-2H-1,2,4-triazole-3-thione;AG-690/36472019;BAS 00367844;EU-0015313
• CAS NO: 122772-21-8
• Molecular Formula: C₁₃H₁₅N₃O₂S
• Molecular Weight: 277.34
• Mol File: 122772-21-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AKOS BBS-00003377(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS BBS-00003377(122772-21-8)
• EPA Substance Registry System: AKOS BBS-00003377(122772-21-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 122772-21-8(Hazardous Substances Data)

Upstream product

• 108903-26-0 C₁₃H₁₇N₃O₃S 
• 41764-74-3 3,4-dimethoxybenzohydrazide 
• 93-07-2 Veratric acid 
• 3943-77-9 ethyl veratrate 

Downstream Products

• 690247-30-4 2-[4-allyl-5-(3,4-dimethoxyphenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-1-phenylethanone 

Relevant articles and documents

New 1,2,4-triazole-Chalcone hybrids induce Caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells

A series of novel 1, 2, 4-triazole/chalcone hybrids was prepared and identified with different spectroscopic techniques. The prepared compounds showed remarkable cytotoxic activity against different cancer cell lines. Compounds 24, 25, 27, 41 and 47 had shown the highest cytotoxicity among the tested compounds against human lung adenocarcinoma A549 cells with IC50 ranging from 4.4 to 16.04 μM compared to cisplatin with IC50 of 15.3 μM. Flow cytometric analysis of the tested compounds showed an increase in the number of apoptotic cells in a dose-dependent manner. The further mechanistic study demonstrated that 1, 2, 4-triazole-chalcone hybrids induced apoptosis via increased level of proapoptotic protein Bax, release of cytochrome c from mitochondria and activation of caspase-3/8/9 proteins. However, general caspase inhibition by the pan-caspase inhibitor, z-VAD-fmk, significantly decreased the apoptosis induced by the tested hybrids, suggesting dependency of apoptosis on activation of the caspase-3 pathway.

New nitric oxide donating 1,2,4-triazole/oxime hybrids: Synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities

A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity. Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin. Calculation of the ulcer indices and histopathological investigation indicated that the prepared NO-donating oximes exhibited less ulcerogenicity compared to their intermediate ketones and indomethacin. The NO-donating oxime 6i revealed significant activity against renal cancer A498 cell lines with 50.52 cell growth inhibition.