1227869-61-5

Basic information

• Product Name: (4,4′,5,5′-tetrachloro-1′H-[1,3′-bipyrrole]-2,2′-diyl)bis((2-methoxyphenyl)methanone)
• CAS NO: 1227869-61-5
• Molecular Weight: 538.214
• Mol File: 1227869-61-5.mol

Chemical Properties

• CAS DataBase Reference: (4,4′,5,5′-tetrachloro-1′H-[1,3′-bipyrrole]-2,2′-diyl)bis((2-methoxyphenyl)methanone)(CAS DataBase Reference)
• NIST Chemistry Reference: (4,4′,5,5′-tetrachloro-1′H-[1,3′-bipyrrole]-2,2′-diyl)bis((2-methoxyphenyl)methanone)(1227869-61-5)
• EPA Substance Registry System: (4,4′,5,5′-tetrachloro-1′H-[1,3′-bipyrrole]-2,2′-diyl)bis((2-methoxyphenyl)methanone)(1227869-61-5)

Safety Data

• Hazardous Substances Data: 1227869-61-5(Hazardous Substances Data)

Upstream product

• 252932-48-2 3-amino-2-ethoxycarbonylpyrrole 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 579-75-9 2-Methoxybenzoic acid 
• 1305334-94-4 1'H-[1,3'-bipyrrol]-2'-yl(2-methoxyphenyl)methanone 
• 1305334-93-3 ethyl 1'H-1,3'-bipyrrole-2'-carboxylate 
• 1227869-59-1 1'H-1,3'-bipyrrole-2,2'-diylbis[(2-methoxyphenyl)methanone] 

Downstream Products

• 1010732-14-5 [4,5-dichloro-1-[4,5-dichloro-2-(2-hydroxybenzoyl)-1H-pyrrol-3-yl]pyrrol-2-yl]-(2-hydroxyphenyl)methanone 
• 1305334-97-7 (4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2'-diyl)bis((2-acetoxyphenyl)methanone) 

Relevant articles and documents

Exploration of the Bis(thio)urea-Catalyzed Atropselective Synthesis of Marinopyrrole A

The marinopyrroles are a new class of natural products with highly interesting biomedical and structural features. We herein provide a concise, nitrogen-protective-group-free synthesis of marinopyrrole A, constituting the as yet most efficient route. The

MCL-1 MODULATING COMPOSITIONS

The present invention relates to marinopyrrole A derivatives and pyoluteorin derivatives and methods of treatment of disorders associated with misregulation of Mcl-l, e.g., leukemia, lymphoma, multiple myeloma, melanoma, or pancreatic cancer. We describe exemplary compounds, which may be contained in pharmaceutical compositions, and their use as therapeutic agents either alone or in combination with other anti-cancer treatments, e.g., anti-Bcl- 2 agents.

Total synthesis and biological evaluation of marinopyrrole A and analogs

A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogs whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.

Total synthesis of (±)-marinopyrrole a via copper-mediated N-arylation

The total synthesis of the racemic form of the marine alkaloid marinopyrrole A is described. The characteristic 1,3′-bipyrrole core was constructed by a copper-mediated N-arylation process under microwave irradiation.

Total synthesis of (±)-Marinopyrrole a and its library as potential antibiotic and anticancer agents

The first total synthesis of marine natural product, (±)- marinopyrrole A, has been accomplished via a nine-step synthesis in an overall yield of 30%. A small focused library based on marinopyrrole has been designed and synthesized. The scope of chemistry was investigated, and a robust chemistry suitable for library synthesis has been developed in the current study. The method that we have developed has made it possible to generate diverse analogues based on structurally novel marinopyrroles for study of potential antibiotic and anticancer activities.