1228-53-1

Basic information

• Product Name: 3-Nitrophenyl sulphone
• Synonyms: BIS(3-NITROPHENYL)SULFONE;BIS(3-NITROPHENYL)SULPHONE;BIS(M-NITROPHENYL) SULFONE;3,3'-DINITRODIPHENYLSULFONE;3,3'-DINITRODIPHENYLSULPHONE;3-Nitrophenyl sulphone;1,1'-sulfonylbis[3-nitro-benzen];1,1'-Sulfonylbis(3-nitrobenzene)
• CAS NO: 1228-53-1
• Molecular Formula: C₁₂H₈N₂O₆S
• Molecular Weight: 308.27
• EINECS: 214-965-2
• Mol File: 1228-53-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 252-255°C
• Boiling Point: 541.1 °C at 760 mmHg
• Flash Point: 281 °C
• Appearance: /
• Density: 1.53 g/cm³
• Vapor Pressure: 1.28E-10mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-Nitrophenyl sulphone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Nitrophenyl sulphone(1228-53-1)
• EPA Substance Registry System: 3-Nitrophenyl sulphone(1228-53-1)

Safety Data

• RTECS: WR4700000
• Hazardous Substances Data: 1228-53-1(Hazardous Substances Data)

Usage

General Description

3-Nitrophenyl sulphone, also known as 3-Nitrobenzenesulfonyl or 3-Nitrophenyl sulfone, is a chemical compound with the molecular formula C6H5NO5S. It is a yellowish crystalline substance that is insoluble in water and has a slightly bitter taste. 3-Nitrophenyl sulphone is commonly used as a reagent in organic synthesis for the preparation of various compounds, particularly for the formation of sulfonamides. It is also used as a precursor for the synthesis of dyes and pharmaceuticals. Additionally, 3-Nitrophenyl sulphone has been studied for its potential use in organic light-emitting diodes (OLEDs) and as a corrosion inhibitor. However, it is important to note that 3-Nitrophenyl sulphone is toxic and should be handled with caution.

InChI:InChI=1/C12H8N2O6S/c15-13(16)9-3-1-5-11(7-9)21(19,20)12-6-2-4-10(8-12)14(17)18/h1-8H

Upstream product

• 139-66-2 diphenyl sulfide 
• 127-63-9 diphenyl sulphone 
• 71-43-2 benzene 
• 7697-37-2 nitric acid 
• 98-95-3 nitrobenzene 
• 945-51-7 1,1'-sulfinylbisbenzene 

Downstream Products

• 599-61-1 3,3'-diaminodiphenyl sulfone 
• 1315509-19-3 3-(3-nitrophenylsulfonyl)aniline 

Relevant articles and documents

Systematic study of synthesizing various heteroatom-substituted rhodamines from diaryl ether analogues

The dye rhodamine, as the most popular scaffold to construct fluorescent labels and probes, has been explored extensively on its structure-fluorescence relationships. Particularly, the replacement of the oxygen atom in the 10th position with heteroatoms obtained various new rhodamines with improved photophysical properties, such as brightness, photostability, red-shifted emission and fluorogenicity. However, the applications of heteroatom-substituted rhodamines have been hindered by difficult synthetic routes. Herein, we explored the condensation strategy of diaryl ether analogues and o-tolualdehyde to synthesize various heteroatom-substituted rhodamines. We found that the electron property and steric effect in the rhodamine 10th position determined the synthetic yield. It's concluded that this condensation method was more suitable for the synthesis of heteroatom-substituted rhodamines with small or electron-donating groups like rhodamine, S-rhodamine and Si-rhodamine. We hope these results will benefit the design and synthesis of heteroatom-substituted rhodamines.

Process for the production of nitro derivatives of aromatic compounds

Nitroderivates of aromatic compounds which are difficult to nitrate, can readily be obtained by nitration providing that the aromatic compound is treated with nitric acid or another nitrating agent in the presence of aliphatic or cycloaliphatic hydrocarbons monosubstituted or polysubstituted by halogen, the nitro group or an alkyl sulphonyl group, and the nitro derivative formed subsequently isolated.