1228014-80-9Relevant academic research and scientific papers
Convenient Entry to 18F-Labeled Amines through the Staudinger Reduction
Stéen, E. Johanna L.,Shalgunov, Vladimir,Denk, Christoph,Mikula, Hannes,Kj?r, Andreas,Kristensen, Jesper L.,Herth, Matthias M.
, p. 1722 - 1725 (2019/01/30)
Fluorine-18 possesses outstanding decay characteristics for positron emission tomography (PET) imaging. Therefore, it is ideally suited for clinical applications. As such, improved strategies to incorporate fluorine-18 into bioactive molecules are of utmo
Copper-mediated reduction of 2-[18F]fluoroethyl azide to 2-[18F]fluoroethylamine
Glaser, Matthias,rstad, Erik,Gaeta, Alessandra,Nairne, James,Trigg, William,Robins, Edward G.
, p. 326 - 331 (2012/11/07)
18F-labelled fluoroalkylamines are attractive reagents for the preparation of positron emission tomography tracers containing amine, amide, and N-heterocyclic moieties. Herein, we report that 2-[18F] fluoroethylamine can be obtained from 2-[18F]fluoroethyl azide by reduction with elemental copper under acidic conditions. Azide to amine reduction was achieved in near quantitative analytical yields within 30 min by heating a solution of 2-[18F]fluoroethyl azide in the presence of copper wire and aqueous trifluoroacetic acid. Subsequent reaction of 2-[ 18F]fluoroethylamine with benzoyl chloride in the presence of triethylamine provided N-[18F]fluoroethyl benzamide in 63% decay-corrected radiochemical yield from 2-[18F]fluoroethyl azide. The utility of the Cu(0)/H+ azide reduction method was further exemplified by preparation of the potential GABAA tracer 9H-β-carboline N-2-[18F]fluoroethylamide, which was obtained in 46% decay-corrected radiochemical yield by reaction of 2-[18F] fluoroethylamine with the corresponding 9H-β-carboline pentafluorophenyl ester. Copyright
APPLICATION OF STAUDINGER LIGATION IN PET IMAGING
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Page/Page column 19; 30, (2011/10/13)
A method for generating a radiolabeled tracer. The method includes providing a phosphine molecule having at least one carbocyclic, aromatic, or pyrrolidinyl ring with an OH substitute. The OH of this phosphines molecule is then condensed with an acid to p
RADIOFLUORINATION
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Page/Page column 22-23, (2010/06/17)
The present invention relates to 18F radiochemistry and in particular to a method for synthesising radiofluorinated amides and amines. The method of the invention has particular application in the radiosynthesis of a variety of 18F-l
