1228016-63-4Relevant academic research and scientific papers
Planar-chiral imidazole-based phosphine ligands derived from [2.2]paracyclophane
Seacome, Richard J.,Coles, Martyn P.,Glover, Jean E.,Hitchcock, Peter B.,Rowlands, Gareth J.
, p. 3687 - 3694 (2010/06/19)
Two planar chiral heteroaryl monophosphines have been synthesised and studied. The phosphines are readily prepared from 4-imidazole[2.2]paracyclophane by selective deprotonation and reaction with the appropriate dialkylchlorophosphines. The planar chiral imidazole was constructed in four steps from readily available [2.2]paracyclophane. The 2-phosphino-N-[2.2] paracyclophanes were active in the Suzuki-Miyaura coupling of aryl bromides and chlorides. Coordination studies indicate P,N-chelation in the solid-state. These studies lay the foundations for asymmetric couplings.
