122804-29-9Relevant academic research and scientific papers
SYNTHESIS OF CLAVULONE DERIVATIVES. SELECTIVE CLEAVAGE OF ESTER BONDS IN CLAVULONE
Iguchi, Kazuo,Kaneta, Soichiro,Nagaoka, Hiroto,Yamada, Yasuji
, p. 157 - 160 (1989)
The clavulone derivatives (1-O-demethylclavulone II and 4-O-deacetylclavulone II) were synthesized from clavulone II (1) by selective enzymatic hydrolisis of 1 using porcin liver esterase (PLE) and orange peel acetylesterase, respectively.The derivative (
SYNTHESIS OF 10-HALOGENATED CLAVULONE DERIVATIVES
Iguchi Kazuo,Kaneta, Soichiro,Tsune, Chieko,Yamada, Yasuji
, p. 1173 - 1175 (2007/10/02)
Epoxidaton of clavulone II (1) with tert-butyl hydroperoxide gave stereoselectively the epoxide 2.Reaction of 2 with lithium chloride gave effectively the 10-chlorinated clavulone derivative 3a.The brominated derivative 3b and iodinated derivative 3c were
