1228120-17-9

Basic information

• Product Name: ethyl 4-acetyl-2-(3-(4-(N-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfamoyl)phenyl)thioureido)-5-methylthiophene-3-carboxylate
• CAS NO: 1228120-17-9
• Molecular Weight: 555.681
• Mol File: 1228120-17-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 4-acetyl-2-(3-(4-(N-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfamoyl)phenyl)thioureido)-5-methylthiophene-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-acetyl-2-(3-(4-(N-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfamoyl)phenyl)thioureido)-5-methylthiophene-3-carboxylate(1228120-17-9)
• EPA Substance Registry System: ethyl 4-acetyl-2-(3-(4-(N-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfamoyl)phenyl)thioureido)-5-methylthiophene-3-carboxylate(1228120-17-9)

Safety Data

• Hazardous Substances Data: 1228120-17-9(Hazardous Substances Data)

Upstream product

• 1148108-84-2 4-isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide 
• 518993-17-4 C₁₀H₁₃NO₃S 

Relevant articles and documents

Synthesis and antitumor activity of some novel pyrazole and thienopyrimidine derivatives

The novel thiosemicarbazide derivative was prepared by hydrazinolysis of isothiocyanatosulfonamide with hydrazine hydrate. It was used as a starting material for the synthesis of some novel pyrazolosulphaphenazole, phthalazine, thiourea, and 1,2,4-triazolbenzenesulfonamide derivatives. Isothiocyanato sulfonamide was cyclized with sulfanyl acetic acid to furnish the novel 2-thioxothiazolidine derivative. Treatment of p-substituted sulfamoylphenyl isothiocyanate derivatives with various O-aminoesters of thiophene derivatives yielded dimethyl thiophene-carboxylate, methylthiophene carboxylate, and thienopyrimidine derivatives. Some of synthesized compounds were evaluated for one cell line. Compounds 3, 9, 15a, 15b, and 18 exhibited remarkable antitumor activity against MCF7 (breast) human cells. Supplemental materials are available for this article. Go to the publisher′s online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.