1148108-84-2

Upstream product

• 463-71-8 thiophosgene 
• 32909-92-5 sulfametrole 

Downstream Products

• 1148108-88-6 4-(3-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)thioureido)-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide 
• 1148108-89-7 4-(2-thioxo-1,2,5,6,7-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidi-4-yl)-1-benzenesulfonamide 
• 1148108-87-5 ethyl 2-(3-(4-(N-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfamoyl)phenyl)thioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 1148108-90-0 N-(4-methoxy-1,2,5-thiadiazol-3-yl)-4-(4-oxo-2-thioxothiazolidin-3-yl)benzenesulfonamide 
• 1148108-85-3 4-(3-amino-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide 
• 1148108-86-4 4-(6,8-dichloro-4-oxo-2-thioxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide 
• 1217859-29-4 4-(3,5-dicyano-4-hydroxythiophen-2-ylamino)-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide 
• 1217859-27-2 4-(4-amino-2-(dicyanomethylene)thiazol-3-(2H)-yl)-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide 
• 1217859-32-9 ethyl 4-cyano-3-hydroxy-5-(4-(N-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfamoyl)phenylamino)thiophene-2-carboxylate 
• 1217859-30-7 4-(2-(dicyanomethylene)-4-oxothiazolidin-3-yl)-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide 
• 1217859-34-1 4-(4-amino-5-benzoyl-3-cyanothiophen-2-ylamino)-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide 
• 1228120-17-9 ethyl 4-acetyl-2-(3-(4-(N-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfamoyl)phenyl)thioureido)-5-methylthiophene-3-carboxylate 
• 1228120-15-7 ethyl 4,5-dimethyl-2-(3-(4-(N-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfamoyl)phenyl)thioureido)thiophene-3-carboxylate 

Relevant academic research and scientific papers

Synthesis and antitumor activity of some novel pyrazole and thienopyrimidine derivatives

The novel thiosemicarbazide derivative was prepared by hydrazinolysis of isothiocyanatosulfonamide with hydrazine hydrate. It was used as a starting material for the synthesis of some novel pyrazolosulphaphenazole, phthalazine, thiourea, and 1,2,4-triazolbenzenesulfonamide derivatives. Isothiocyanato sulfonamide was cyclized with sulfanyl acetic acid to furnish the novel 2-thioxothiazolidine derivative. Treatment of p-substituted sulfamoylphenyl isothiocyanate derivatives with various O-aminoesters of thiophene derivatives yielded dimethyl thiophene-carboxylate, methylthiophene carboxylate, and thienopyrimidine derivatives. Some of synthesized compounds were evaluated for one cell line. Compounds 3, 9, 15a, 15b, and 18 exhibited remarkable antitumor activity against MCF7 (breast) human cells. Supplemental materials are available for this article. Go to the publisher′s online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

Synthesis of thiazolidine and thiophene derivatives for evaluation as anticancer agents

The non-isolated adducts (3a,b) were used as key intermediates to synthesize some novel thiazolidine and thiophene derivatives. Compound (4) exhibited a remarkable antitumor activity against EAC cells compared with the Doxorubicin as a positive control. T

Antitumor activity of some novel 1,2,5-thiadiazole derivatives

Some novel thiourea,1,2,4-triazole, quinazoline, thieno[2,3-d]pyrimi-dine, and thiazolidine derivatives were synthesized to evaluate their antitumor activity. Compound (3f) is nearly as active as reference drug, (Doxorubicin) as positive control.