1228170-53-3Relevant academic research and scientific papers
Identification of potent, highly constrained CGRP receptor antagonists
Stump, Craig A.,Bell, Ian M.,Bednar, Rodney A.,Fay, John F.,Gallicchio, Steven N.,Hershey, James C.,Jelley, Richard,Kreatsoulas, Constantine,Moore, Eric L.,Mosser, Scott D.,Quigley, Amy G.,Roller, Shane A.,Salvatore, Christopher A.,Sharik, Steven S.,Theberge, Cory R.,Zartman, C. Blair,Kane, Stefanie A.,Graham, Samuel L.,Selnick, Harold G.,Vacca, Joseph P.,Williams, Theresa M.
, p. 2572 - 2576 (2010)
A novel series of potent CGRP receptor antagonists containing a central quinoline ring constraint was identified. The combination of the quinoline constraint with a tricyclic benzimidazolinone left hand fragment produced an analog with picomolar potency (
