1228180-96-8Relevant articles and documents
Copper(I)-Catalyzed Enyne Oxidation/Cyclopropanation: Divergent and Enantioselective Synthesis of Cyclopropanes
Shen, Wen-Bo,Tang, Xiang-Ting,Zhang, Ting-Ting,Lv, Dong-Can,Zhao, Dan,Su, Tong-Fu,Meng, Lei
, p. 1285 - 1290 (2021)
An efficient copper(I)-catalyzed enyne oxidation/cyclopropanation for the modular synthesis of cyclopropane derivatives is described, which represents the first non-noble metal-catalyzed enynes oxidation/cyclopropanation by the in situ generated α-oxo copper carbenes. This protocol allows the assembly of valuable cyclopropane-γ-lactams in generally good to excellent yields with excellent diastereoselectivity. More significantly, the enantioselective version of enyne oxidation/cyclopropanation has been disclosed with chiral copper catalysts.
Enantioselective Copper-Catalyzed Desymmetrization of 1,3-Diketones Involving Borylation of Styrenes
Zheng, Purui,Han, Xiaoyu,Hu, Jiao,Zhao, Xiaoming,Xu, Tao
supporting information, p. 6040 - 6044 (2019/08/27)
A copper-catalyzed intramolecular enantioselective and diastereoselective borylative coupling of styrenes and ketones was achieved by merging desymmetrization strategy and olefin difunctionalization. The reaction proceeds through an initial enantioselective borylcupration of styrenes, followed by a highly selective direct addition to 1,3-diketones. The bicyclic scaffolds with three chiral carbon centers, including two tetrasubstituted carbons, were generated in excellent yields, diastereoselectivities, and enantioselectivities. This catalytic tandem reaction has great potential for further synthetic application of the chiral polycyclic compounds, because of the versatility of the functional groups in the products.
AgOTf-catalyzed sequential synthesis of 4-isoquinolones: Via oxidative ring opening of aziridines and aza-Michael addition
Xing, Siyang,Cui, Hong,Gu, Nan,Li, Ying,Wang, Kui,Tian, Dawei,Qin, Jiajing,Liu, Qiaoyang
supporting information, p. 8308 - 8312 (2017/10/23)
An efficient AgOTf-catalyzed sequential reaction involving the oxidative ring-opening of aziridines by DMSO and aza-Michael addition has been developed. A series of 2,3-dihydro-4(1H)-isoquinolones were afforded in moderate to good yields by the formation of one new CO bond and one new C-N bond. The features of this sequential reaction include high bonding efficiency, use of a catalytic amount of catalysts, a broad substrate scope and mild conditions. This methodology provides a good choice for constructing the libraries of 2,3-dihydro-4(1H)-isoquinolones.