1228186-99-9

Basic information

• Product Name: ethyl (1S,2S,5S)-2-(tert-butoxycarbonylamino)-5-hydroxycyclohex-3-enecarboxylate
• Synonyms: ethyl (1S,2S,5S)-2-(tert-butoxycarbonylamino)-5-hydroxycyclohex-3-enecarboxylate
• CAS NO: 1228186-99-9
• Molecular Weight: 285.34
• Mol File: 1228186-99-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl (1S,2S,5S)-2-(tert-butoxycarbonylamino)-5-hydroxycyclohex-3-enecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (1S,2S,5S)-2-(tert-butoxycarbonylamino)-5-hydroxycyclohex-3-enecarboxylate(1228186-99-9)
• EPA Substance Registry System: ethyl (1S,2S,5S)-2-(tert-butoxycarbonylamino)-5-hydroxycyclohex-3-enecarboxylate(1228186-99-9)

Safety Data

• Hazardous Substances Data: 1228186-99-9(Hazardous Substances Data)

Upstream product

• 1334880-42-0 tert-butyl (1R,2S,5S)-7-oxo-6-oxabicyclo[3.2.1]oct-3-en-2-ylcarbamate 
• 141-52-6 sodium ethanolate 
• 20205-48-5 8-oxo-7-azabicyclo<4.2.0>oct-2-ene 
• 189125-29-9 (1R,2S)-cis-2-aminocyclohex-4-enecarboxylic acid 
• 1334880-41-9 tert-butyl (1R,2S,4S,5S)-4-iodo-7-oxo-6-oxabicyclo[3.2.1]octan-2-ylcarbamate 
• 1226812-49-2 (1R,6S)-6-(tert-butoxycarbonylamino)cyclohex-3-enecarboxylic acid 

Downstream Products

• 1228187-00-5 ethyl (1S,2S,5R)-2-(tert-butoxycarbonylamino)-5-hydroxycyclohexanecarboxylate 
• 1334880-63-5 ethyl (1S,2S,5S)-2-(tert-butoxycarbonylamino)-5-fluorocyclohexanecarboxylate 

Relevant articles and documents

Selective nitrile oxide dipolar cycloaddition for the synthesis of highly functionalized β-aminocyclohexanecarboxylate stereoisomers

Highly functionalized β-aminocyclohexanecarboxylate regio- and stereoisomers were synthesized from a bicyclic β-lactam by successive regioselective iodolactonization, stereo- and regioselective nitrile oxide cycloaddition, lactone ring-opening and isoxazoline ring-opening.

Direct enzymatic route for the preparation of novel enantiomerically enriched hydroxylated β-amino ester stereoisomers

Enantiomerically enriched hydroxy-substituted β-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee ≥ 52%) were obtained when the CAL-Bcatalyzed reactions