1228243-07-9Relevant academic research and scientific papers
Novel one-pot, four-component condensation reaction: An efficient approach for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives by a ugi-4CR/ aza -wittig sequence
Ramazani, Ali,Rezaei, Aram
supporting information; experimental part, p. 2852 - 2855 (2010/08/20)
(Figure presented) A novel and efficient method has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives using (N-isocyanimino)triphenylphosphorane, a secondary amine, a carboxylic acid, and an aromatic aldehyde in CH2Cl2 at ambient temperature in high yields without using any catalyst or activation. The procedure provides an alternative method to the synthesis of fully substituted 1,3,4-oxadiazole derivatives.
