1228268-91-4

Upstream product

• 100-63-0 phenylhydrazine 
• 829-20-9 2',4'-dimethoxyacetophenone 
• 294656-67-0 2,4-dimethoxy-acetophenone-phenylhydrazone 
• 68-12-2 N,N-dimethyl-formamide 
• 18997-06-3 N,N-Dimethyl-formamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT 

Downstream Products

• 1431855-47-8 2-(2,4-dimethoxyphenylamino)-5-[3-(2,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]thiazol-4-one 
• 1228268-92-5 C₂₅H₂₂N₆O₂ 
• 1228268-98-1 C₂₇H₂₄N₆O₃S 
• 1253857-25-8 5-((3-(2,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)pyrimidin-2,4,6-trione 

Relevant academic research and scientific papers

Synthesis, docking, in vitro and in vivo antidiabetic activity of pyrazole-based 2,4-thiazolidinedione derivatives as PPAR-γ modulators

The design, synthesis, structure–activity relationship, and biological activity of 2,4-thiazolidinedione derivatives as peroxisome proliferator-activated receptor-γ (PPAR-γ) modulators for antidiabetic activity are reported. Fifteen 2,4-thiazolidinedione

Synthesis of new heterocyclic hybrids based on pyrazole and thiazolidinone scaffolds as potent inhibitors of tyrosinase

As a part of ongoing studies in developing new Tyrosinase inhibitors, a class of structurally novel 2-(2,4-dimethoxy phenylamino)-5 methylene-4- thiazolinone derivatives were synthesized by incorporating 2-(2,4-dimethoxy- phenylamino)-thiazol-4-one with various 1-(1-methyl-buta-1,3-dienyl)-3-phenyl- 1H-pyrazole-4-carbaldehyde. The results showed that some of the synthesized compounds exhibited significant inhibitory activities. Especially, 5-[3-(2-chloro-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2, 4-dimethoxy-phenylamino)-thiazol-4-one (5h) and 5-[3-(3-chloro-phenyl)-1-phenyl- 1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxy-phenylamino)-thiazol-4-one (5g) possessing 2-chloro-phenyl and 3-chloro-phenyl group exhibited the most potent tyrosinase inhibitory activity with an IC50 value of 34.12 and 52.62 μM, respectively. The inhibition mechanism analysis of 5h and 5g thiazolidinone derivatives demonstrated that the inhibitory effects of the compounds on tyrosinase were reversible and competitive. Preliminary structure-activity relationships (SAR) analysis suggested that further development of such compounds might be of interest, as it manifests simple reversible slow binding inhibition against monophenolase and diphenolase.