1228275-95-3

Upstream product

• 1228275-94-2 (E)-3-(5'-acetyl-2',4',6-trimethoxybiphenyl-3-yl)-1-(2,4-dimethoxyphenyl)prop-2-en-1-one 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1228275-96-4 4,2',4'',2'''-tetraoxy-4',4'''-dimethoxy-3,5'''-bichalcone 
• 1228275-97-5 4,2',4',4'',2'''-pentahydroxy-4'''-methoxy-3,5'''-bichalcone 

Relevant academic research and scientific papers

Total synthesis, antiprotozoal and cytotoxicity activities of rhuschalcone VI and analogs

The total synthesis of a potent antiplasmodial natural bichalcone, rhuschalcone VI, is described starting from simple and available resorcinol and 4-hydroxybenzaldehyde. Key steps include the solvent-free Aldol syntheses of chalcones, and the successful application of the Suzuki-Miyaura coupling reaction in the synthesis of bichalcones. The present work constitutes a general method for the rapid syntheses of a number of bichalcones related to rhuschalcone VI. Some of the bichalcones showed moderate antiprotozoal activities against Bodo caudatus, a preliminary screening system for antitrypanosomal activities, most of them with little or no cytotoxicity.