1228276-01-4Relevant academic research and scientific papers
Total synthesis, antiprotozoal and cytotoxicity activities of rhuschalcone VI and analogs
Mihigo, Shetonde O.,Mammo, Wendimagegn,Bezabih, Merhatibeb,Andrae-Marobela, Kerstin,Abegaz, Berhanu M.
experimental part, p. 2464 - 2473 (2010/07/02)
The total synthesis of a potent antiplasmodial natural bichalcone, rhuschalcone VI, is described starting from simple and available resorcinol and 4-hydroxybenzaldehyde. Key steps include the solvent-free Aldol syntheses of chalcones, and the successful application of the Suzuki-Miyaura coupling reaction in the synthesis of bichalcones. The present work constitutes a general method for the rapid syntheses of a number of bichalcones related to rhuschalcone VI. Some of the bichalcones showed moderate antiprotozoal activities against Bodo caudatus, a preliminary screening system for antitrypanosomal activities, most of them with little or no cytotoxicity.
