1228276-99-0

Upstream product

• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 67828-69-7 methyl 5-chloro-2,4-dihydroxybenzoate 
• 705963-54-8 1-[2,4-bis(benzyloxy)-5-chlorophenyl]ethan-1-one 
• 90110-32-0 1-(5-chloro-2,4-dihydroxyphenyl)ethan-1-one 
• 95-88-5 4-Chlororesorcinol 
• 912545-04-1 2,4-bis(benzyloxy)-5-chlorobenzoic acid 

Downstream Products

• 1228277-02-8 3-(5-chloro-2,4-dihydroxyphenyl)-1,5,6,7-tetrahydropyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester 
• 1228277-03-9 3-(5-chloro-2,4-dihydroxyphenyl)-1,4,5,7-tetrahydropyrazolo[3,4-c]pyridine-6-carboxylic acid tert-butyl ester 
• 1228276-98-9 1-benzyl-3-(2,4-bisbenzyloxy-5-chlorobenzoyl)piperidin-4-one 

Relevant academic research and scientific papers

SUBSTITUTED PYRIDINONE-CONTAINING TRICYCLIC COMPOUNDS, AND METHODS USING SAME

The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.

RESORCINOL N-ARYL AMIDE COMPOUNDS, FOR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS

A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Y is –CONR1- or optionally substituted arylene or optionally substituted heteroarylene; R1 is H, Cl, F, CH3 or CF3; 10 each R4 is independently H, CH3 or F; R5 is H or CH3; and each R2 and R6 is independently (Alk)n-Rn-(Alk)n-Rn-(Alk)n-X; The compounds of the invention are useful as resorcinol N-aryl amide (NAA) compounds, which are suitable for use as PDK inhibitors, for example for 15 inhibition of cancer cell proliferation.