1228306-33-9Relevant academic research and scientific papers
First metal-containing histamine H3 receptor ligands
Sander, Kerstin,Kottke, Tim,Hoffend, Claas,Walter, Miriam,Weizel, Lilia,Camelin, Jean-Claude,Ligneau, Xavier,Schneider, Erich H.,Seifert, Roland,Schwartz, Jean-Charles,Stark, Holger
supporting information; experimental part, p. 2578 - 2581 (2010/10/02)
Iron-containing ligands targeting the human histamine H3 receptor (hH3R) were prepared. The compounds contain ferrocene sandwich complexes coupled via different linkers to a basic hH3R antagonist/inverse agonist pharmacophore. In a click chemistry approach, a triazole was successfully inserted as a new linking element. Two ferrocenylmethylamines and a ferrocenyltriazole were the most affine hH 3R ligands within this series, showing receptor binding in the nano- and subnanomolar concentration range.
