1228306-36-2

Downstream Products

• 1228306-33-9 1-(3-(4-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)phenoxy)propyl)piperidine 
• 1345192-69-9 1-{3-[4-(1H-1,2,3-triazol-1-ylmethyl)phenoxy]propyl}piperidine 
• 1345192-59-7 {1-[4-(3-piperidin-1-ylpropoxy)benzyl]-1H-1,2,3-triazol-4-yl}methanol 
• 1345192-65-5 methyl 1-[4-(3-piperidin-1-ylpropoxy)benzyl]-1H-1,2,3-triazole-4-carboxylate 
• 1345192-62-2 1-[4-(3-piperidin-1-ylpropoxy)benzyl]-1H-1,2,3-triazole-4-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of 1,2,3-triazole elements in histamine H3 receptor ligands

1,2,3-Triazole moieties were introduced in a histamine H3 receptor antagonist pharmacophore blueprint with a versatile click chemistry approach, yielding potent ligands. Azide and alkynes were combined under copper(I) catalysis to provide the t

First metal-containing histamine H3 receptor ligands

Iron-containing ligands targeting the human histamine H3 receptor (hH3R) were prepared. The compounds contain ferrocene sandwich complexes coupled via different linkers to a basic hH3R antagonist/inverse agonist pharmacophore. In a click chemistry approach, a triazole was successfully inserted as a new linking element. Two ferrocenylmethylamines and a ferrocenyltriazole were the most affine hH 3R ligands within this series, showing receptor binding in the nano- and subnanomolar concentration range.