122833-58-3

Usage

Uses

Used in Organic Synthesis:
(1R,2R)-1,2-N,N'-BIS[(METHANE-SULFONYL)AMINO]-CYCLOHEXANE is used as a reagent in organic synthesis for the formation of chiral compounds. Its unique structure allows for selective reactions, contributing to the synthesis of complex organic molecules with specific stereochemistry.
Used in Medicinal Chemistry and Pharmaceutical Research:
Due to its chiral nature and the presence of amine groups, which are common in biologically active molecules, (1R,2R)-1,2-N,N'-BIS[(METHANE-SULFONYL)AMINO]-CYCLOHEXANE may have potential applications in medicinal chemistry and pharmaceutical research. It can be utilized in the development of new drugs and therapeutic agents.
Used as a Protecting Group in Organic Synthesis:
The methanesulfonyl groups in (1R,2R)-1,2-N,N'-BIS[(METHANE-SULFONYL)AMINO]-CYCLOHEXANE can act as protecting groups for amines, enabling selective reactions in organic synthesis. This property is valuable in the synthesis of complex molecules where the protection and subsequent deprotection of functional groups are necessary to achieve the desired product.

Upstream product

• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 124-63-0 methanesulfonyl chloride 

Relevant academic research and scientific papers

Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (5-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants

The role played by stereochemistry in the C2-substituent (left part) on the S-DABO scaffold for anti-HIV-1 activity has been investigated for the first time. A series of S-DABO analogues, where the double bond in the C2-substituent is replaced by an enant

Catalytic enantioselective cyclopropanation with bis(halomethyl) zinc reagents. II. The effect of promoter structure on selectivity

The catalytic, enantioselective cyclopropanation of cinnamyl alcohol has been accomplished with bis (iodomethyl)zinc in the presence of chiral bis(sulfonamides) derived from cyclohexanediamine. An extensive survey of diamine and sulfonamide structure has revealed a marked sensitivity to the spatial relationship of the amine groups, but only a modest dependence on the sulfonamide residue.

A Catalytic Enantioselective Reaction Using a C2-Symmetric Disulfonamide as a Chiral Ligand: Alkylation of Aldehydes Catalyzed by Disulfonamide-Ti(O-i-Pr)4-Dialkyl Zinc System

Excellent enantioselective alkylation of aldehydes with dialkylzinc has been developed.This methodology is based on the concept of modifying the Lewis acid with a C2-symmetric, electron-withdrawing disulfonamide.The chiral Lewis acid catalysts used in the present study are the titanium complexes, prepared in-situ from disulfonamide and Ti(O-i-Pr)4.Key Words: Chiral disulfonamide; chiral titanium complex; enantioselective alkylation; dialkyl zinc; catalytic reaction