1228384-01-7

Basic information

• Product Name: 4'-benzyl-4-methyl-2'-phenyl-2,5'-bipyrimidine-5-carbonitrile
• CAS NO: 1228384-01-7
• Molecular Weight: 363.421
• Mol File: 1228384-01-7.mol

Chemical Properties

• CAS DataBase Reference: 4'-benzyl-4-methyl-2'-phenyl-2,5'-bipyrimidine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-benzyl-4-methyl-2'-phenyl-2,5'-bipyrimidine-5-carbonitrile(1228384-01-7)
• EPA Substance Registry System: 4'-benzyl-4-methyl-2'-phenyl-2,5'-bipyrimidine-5-carbonitrile(1228384-01-7)

Safety Data

• Hazardous Substances Data: 1228384-01-7(Hazardous Substances Data)

Upstream product

• 885121-98-2 (E/Z)-2-((dimethylamino)methylene)-3-oxobutanenitrile 

Relevant articles and documents

ALPHA-HELIX MIMETIC USING A 2,5-OLIGOPYRIMIDINE SCAFFOLD

Alpha-helix mimetics and associated methods of making are provided. These compounds are constructed using a 2,5-oligopyrimidine scaffold. The semi-rigid scaffold holds individual side chain-like residues in orientations that mimic the orientations of side chain residues of an ?-helical protein domain. The new scaffold is easier to make than previous scaffolds and has much more favorable physical properties than previous alpha-helix mimics. The amphiphilic alpha-helix mimetics have application for making libraries and for treating diseases or conditions effected by the inhibition or disruption of interactions with the alpha helix of a protein.

Facile iterative synthesis of 2,5-terpyrimidinylenes as nonpeptidic α-helical mimics

A facile iterative synthesis of 2,5-terpyrimidinylenes that are structurally analogous to α-helix mimics is presented. Condensation of amidines with readily prepared α,β-unsaturated α-cyanoketones gives 5-cyano-substituted pyrimidines. Iterative transformation of the 5-cyano group into an amidine allows synthesis of 2,5-terpyrimidinylenes with variable groups at the 4-, 4′-, and 4′′-positions. These compounds are designed to mimic the i, i + 4, and i + 7 sites of an α-helix.