885121-98-2

Usage

Appearance

Yellow solid

Chemical classification

Organic compound

Primary use

Intermediate in the synthesis of pharmaceuticals and other organic compounds

Building block

Used in the production of various drugs

Biological activity

Potential therapeutic properties

Applications

Pharmaceutical industry, chemical research, synthesis as a key reagent

Specific content

1. Molecular formula: C8H11NO
2. Appearance: Yellow solid
3. Primary use: Intermediate in the synthesis of pharmaceuticals
4. Building block: Used in the production of various drugs
5. Biological activity: Potential therapeutic properties
6. Applications: Pharmaceutical industry, chemical research, synthesis as a key reagent

Upstream product

• 2469-99-0 Cyanoaceton 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 2407-68-3 3-dimethylaminoacrylonitrile 
• 64-19-7 acetic acid 

Downstream Products

• 1228384-01-7 4'-benzyl-4-methyl-2'-phenyl-2,5'-bipyrimidine-5-carbonitrile 
• 131661-41-1 3-methyl-1H-pyrazole-4-carbonitrile 

Relevant academic research and scientific papers

A kind of fluorine-containing methyl pyrazole compound production method

The invention discloses a co-production method of fluorine-containing methylpyrazole compounds. The fluorine-containing methylpyrazole compounds as shown in formula X or formula XI are prepared from a 3-methyl-1H-pyrazole derivative as shown in the formula III by co-production of optional chlorination, fluorination, methylation and hydrolyzation processes, wherein the optional chlorination reaction is realized by controlling chlorine dosage and reaction temperature in one step. The co-production method is high in product purity and yield and low in cost, and is suitable for industrial co-production of 3-difluoromethyl-1H-methylpyrazole-4-carboxylic acid and 3-trifluoromethyl-1H-methylpyrazole-4-carboxylic acid.

ALPHA-HELIX MIMETIC USING A 2,5-OLIGOPYRIMIDINE SCAFFOLD

Alpha-helix mimetics and associated methods of making are provided. These compounds are constructed using a 2,5-oligopyrimidine scaffold. The semi-rigid scaffold holds individual side chain-like residues in orientations that mimic the orientations of side chain residues of an ?-helical protein domain. The new scaffold is easier to make than previous scaffolds and has much more favorable physical properties than previous alpha-helix mimics. The amphiphilic alpha-helix mimetics have application for making libraries and for treating diseases or conditions effected by the inhibition or disruption of interactions with the alpha helix of a protein.

Facile iterative synthesis of 2,5-terpyrimidinylenes as nonpeptidic α-helical mimics

A facile iterative synthesis of 2,5-terpyrimidinylenes that are structurally analogous to α-helix mimics is presented. Condensation of amidines with readily prepared α,β-unsaturated α-cyanoketones gives 5-cyano-substituted pyrimidines. Iterative transformation of the 5-cyano group into an amidine allows synthesis of 2,5-terpyrimidinylenes with variable groups at the 4-, 4′-, and 4′′-positions. These compounds are designed to mimic the i, i + 4, and i + 7 sites of an α-helix.