885121-98-2Relevant articles and documents
A kind of fluorine-containing methyl pyrazole compound production method
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Paragraph 0051-0052, (2020/02/08)
The invention discloses a co-production method of fluorine-containing methylpyrazole compounds. The fluorine-containing methylpyrazole compounds as shown in formula X or formula XI are prepared from a 3-methyl-1H-pyrazole derivative as shown in the formula III by co-production of optional chlorination, fluorination, methylation and hydrolyzation processes, wherein the optional chlorination reaction is realized by controlling chlorine dosage and reaction temperature in one step. The co-production method is high in product purity and yield and low in cost, and is suitable for industrial co-production of 3-difluoromethyl-1H-methylpyrazole-4-carboxylic acid and 3-trifluoromethyl-1H-methylpyrazole-4-carboxylic acid.
Facile iterative synthesis of 2,5-terpyrimidinylenes as nonpeptidic α-helical mimics
Anderson, Laura,Zhou, Mingzhou,Sharma, Vasudha,McLaughlin, Jillian M.,Santiago, Daniel N.,Fronczek, Frank R.,Guida, Wayne C.,McLaughlin, Mark L.
supporting information; experimental part, p. 4288 - 4291 (2010/08/06)
A facile iterative synthesis of 2,5-terpyrimidinylenes that are structurally analogous to α-helix mimics is presented. Condensation of amidines with readily prepared α,β-unsaturated α-cyanoketones gives 5-cyano-substituted pyrimidines. Iterative transformation of the 5-cyano group into an amidine allows synthesis of 2,5-terpyrimidinylenes with variable groups at the 4-, 4′-, and 4′′-positions. These compounds are designed to mimic the i, i + 4, and i + 7 sites of an α-helix.
