122851-69-8

Basic information

• Product Name: 3-bromo-2-(chloromethyl)pyridine
• Synonyms: 3-bromo-2-(chloromethyl)pyridine
• CAS NO: 122851-69-8
• Molecular Formula: C₆H₅BrClN
• Molecular Weight: 206.47
• Mol File: 122851-69-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 46-46.5 °C(Solv: hexane (110-54-3); ethyl ether (60-29-7))
• Boiling Point: 237.949 °C at 760 mmHg
• Flash Point: 97.709 °C
• Appearance: /
• Density: 1.632 g/cm³
• Vapor Pressure: 0.067mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 1.35±0.22(Predicted)
• CAS DataBase Reference: 3-bromo-2-(chloromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-2-(chloromethyl)pyridine(122851-69-8)
• EPA Substance Registry System: 3-bromo-2-(chloromethyl)pyridine(122851-69-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 122851-69-8(Hazardous Substances Data)

Usage

General Description

3-bromo-2-(chloromethyl)pyridine is a chemical compound with the molecular formula C6H5BrClN. It is a pyridine derivative with a bromine atom at the 3-position and a chloromethyl group at the 2-position. 3-bromo-2-(chloromethyl)pyridine is used as a versatile building block in organic synthesis, particularly in the pharmaceutical industry. It can be used in the preparation of various biologically active compounds, such as antiviral agents and potential drugs for treating cancer and other diseases. Additionally, it is also used in the synthesis of agrochemicals and fine chemicals, making it a valuable intermediate in the production of various commercial products. However, it is important to handle this compound with care, as it is toxic and may cause skin and eye irritation.

InChI:InChI=1/C6H5BrClN/c7-5-2-1-3-9-6(5)4-8/h1-3H,4H2

Upstream product

• 53636-56-9 methyl 3-bromopicolinate 
• 52378-64-0 3-bromo-2-hydroxymethyl-pyridine 

Downstream Products

• 2245084-40-4 tert-butyl 5-oxo-5,7-dihydrospiro[cyclopenta[b]pyridine-6,4’-piperidine]-1‘-carboxylate 
• 122851-60-9 2-(3-bromopyridin-2-yl)acetonitrile 

Relevant articles and documents

PYRIMIDINE AND FIVE-MEMBERED NITROGEN HETEROCYCLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF

The present invention relates to a pyrimidine and a five-membered nitrogen heterocycle derivative, a preparation method therefor, and the medical uses thereof. Particularly, the present invention relates to a pyrimidine and a five-membered nitrogen hetero

Salt of nitrogen-containing heteroaromatic derivative and crystal form thereof

The invention relates to a salt of a nitrogen-containing heteroaromatic derivative and a crystal form thereof. The invention specifically relates to a salt with a general formula (I) and a crystal form thereof. A preparation method and a pharmaceutical composition containing the salt of the derivative and a crystal form thereof, as a protein tyrosine phosphatase - 2C (SHP2) inhibitor, and application thereof to treatment of diseases or diseases such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colon cancer.

IMIDAZOLYLMETHYLTHIOETHYL DITHIOCARBAMATE COMPOUNDS

The compounds are dithiocarbamates and isothioureas which are histamine H 2-antagonists. Two compounds of the invention are 2-(5-methyl-4-imidazolylmethylthio)ethyl N-methyldithiocarbamate and S-[2-(5-methyl-4-imidazolyl-methylthio)ethyl]-N-cyano-N'-methylisothiourea.